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《Nature，10月16日，Rabies virus-based COVID-19 vaccine CORAVAX? induces high levels of neutralizing antibodies against SARS-CoV-2》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-11-16

  • Rabies virus-based COVID-19 vaccine CORAVAX™ induces high levels of neutralizing antibodies against SARS-CoV-2
    Drishya Kurup, Christoph Wirblich, Holly Ramage & Matthias J. Schnell
    npj Vaccines volume 5, Article number: 98 (2020)

    Abstract
    The recently emerged coronavirus SARS-CoV-2, the causative agent of COVID-19, is rapidly spreading in the world. The exponentially expanding threat of SARS-CoV-2 to global health highlights the urgent need for a vaccine. Herein we show the rapid development of a novel, highly efficient, and safe COVID-19 vaccine using a rabies virus-based vector that has proven to be an efficient vaccine against several emerging infectious diseases. This study reports that both a live and an inactivated rabies virus containing the SARS-CoV-2 spike S1 protein induces potent virus-neutralizing antibodies at much higher levels than seen in the sera of convalescent patients. In summary, the results provided here warrant further development of this safe and established vaccine platform against COVID-19.

  • 原文来源：https://www.nature.com/articles/s41541-020-00248-6
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    • 编译者：zhangmin
    • 发布时间：2020-07-28
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