《Nature,5月13日,Clinical features of coronavirus disease 2019 (COVID-19) in a cohort of patients with disability due to spinal cord injury》

  • 来源专题:COVID-19科研动态监测
  • 编译者: zhangmin
  • 发布时间:2020-05-14
  • Clinical features of coronavirus disease 2019 (COVID-19) in a cohort of patients with disability due to spinal cord injury

    Miguel Rodríguez-Cola, Irena Jiménez-Velasco, Francisco Gutiérrez-Henares, Elisa López-Dolado, Claudia Gambarrutta-Malfatti, Eduardo Vargas-Baquero & Ángel Gil-Agudo

    Spinal Cord Series and Cases volume 6, Article number: 39 (2020)

    Abstract

    Study design

    Cohort study of patients with spinal cord injury (SCI).

    Objectives

    To describe the clinical and analytical features of a coronavirus disease 2019 (Covid-19) infected cohort with SCI to enable accurate diagnosis and to outline prevention measures.

    Setting

    This study was conducted at the National Hospital for Paraplegics (Toledo, Spain).

  • 原文来源:https://www.nature.com/articles/s41394-020-0288-3
相关报告
  • 《Nature,9月13日,Obesity is a potential risk factor contributing to clinical manifestations of COVID-19》

    • 来源专题:COVID-19科研动态监测
    • 编译者:zhangmin
    • 发布时间:2020-09-16
    • Obesity is a potential risk factor contributing to clinical manifestations of COVID-19 Zhenyu Kang, Shanshan Luo, Yang Gui, Haifeng Zhou, Zili Zhang, Chunxia Tian, Qiaoli Zhou, Quansheng Wang, Yu Hu, Heng Fan & Desheng Hu International Journal of Obesity (2020) Abstract Background Since December 2019, novel coronavirus (SARS-CoV-2)-induced pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. COVID-19 patients demonstrated significantly different outcomes in clinic. We aimed to figure out whether obesity is a risk factor influencing the progression and prognosis of COVID-19. Methods 95 patients with COVID-19 were divided into obesity group and non-obesity group according to their body mass index (BMI). The demographic data, clinical characteristics, laboratory examination, and chest computed tomography (CT) were collected, analyzed and compared between two groups. Results Our data showed that COVID-19 patients with obesity had more underlying diseases and higher mortality rate compared to those without obesity. Furthermore, patients with obesity also demonstrated more severe pathological change in lung and higher blood lymphocytes, triglycerides, IL-6, CRP, cystatin C, alanine aminotransferase (ALT), erythrocyte sedimentation rate (ESR), which may greatly influence disease progression and poor prognosis of COVID-19.
  • 《Lancet,5月28日,Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study》

    • 来源专题:COVID-19科研动态监测
    • 编译者:zhangmin
    • 发布时间:2020-05-29
    • Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study Nicole M Kuderer, MD † Toni K Choueiri, MD † Dimpy P Shah, PhD † Yu Shyr, PhD † Samuel M Rubinstein, MD Donna R Rivera, PharmD et al. Published:May 28, 2020DOI:https://doi.org/10.1016/S0140-6736(20)31187-9 Summary Background Data on patients with COVID-19 who have cancer are lacking. Here we characterise the outcomes of a cohort of patients with cancer and COVID-19 and identify potential prognostic factors for mortality and severe illness. Methods In this cohort study, we collected de-identified data on patients with active or previous malignancy, aged 18 years and older, with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection from the USA, Canada, and Spain from the COVID-19 and Cancer Consortium (CCC19) database for whom baseline data were added between March 17 and April 16, 2020. We collected data on baseline clinical conditions, medications, cancer diagnosis and treatment, and COVID-19 disease course. The primary endpoint was all-cause mortality within 30 days of diagnosis of COVID-19. We assessed the association between the outcome and potential prognostic variables using logistic regression analyses, partially adjusted for age, sex, smoking status, and obesity. This study is registered with ClinicalTrials.gov, NCT04354701, and is ongoing.