COVID-19 in 7780 pediatric patients: A systematic review
Ansel Hoang
Kevin Chorath †
Axel Moreira
Mary Evans
Finn Burmeister-Morton
Fiona Burmeister
et al.
Open AccessPublished:June 26, 2020DOI:https://doi.org/10.1016/j.eclinm.2020.100433
Abstract
Background
Studies summarizing the clinical picture of COVID-19 in children are lacking. This review characterizes clinical symptoms, laboratory, and imaging findings, as well as therapies provided to confirmed pediatric cases of COVID-19.
Methods
Adhering to PRISMA guidelines, we searched four medical databases (PubMed, LitCovid, Scopus, WHO COVID-19 database) between December 1, 2019 to May 14, 2020 using the keywords “novel coronavirus”, “COVID-19” or “SARS-CoV-2”. We included published or in press peer-reviewed cross-sectional, case series, and case reports providing clinical signs, imaging findings, and/or laboratory results of pediatric patients who were positive for COVID-19. Risk of bias was appraised through the quality assessment tool published by the National Institutes of Health. PROSPERO registration # CRD42020182261.
