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《Nature，6月25日，Potential contribution of increased soluble IL-2R to lymphopenia in COVID-19 patients》

  • 来源专题：COVID-19科研动态监测
  • 编译者： xuwenwhlib
  • 发布时间：2020-06-29

  • Potential contribution of increased soluble IL-2R to lymphopenia in COVID-19 patients

    Yaguang Zhang, Xiaojing Wang, Xuezhen Li, Dong Xi, Ruizhi Mao, Xiaohui Wu, Shipeng Cheng, Xiaoyu Sun, Chunyan Yi, Zhiyang Ling, Liyan Ma, Qin Ning, Yiru Fang, Bing Sun & Di Wu

    Cellular & Molecular Immunology (2020)

    Since the outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), more than 6 million cases are confirmed and over 300,000 cases are dead after infection. Dysfunction of immunity in COVID-19 patients has been considered as one of the fatal factors for patients, especially cytokine release syndrome and lymphopenia.1,2,3 The reduced number and increased exhaustion level of lymphocyte are associated with elevated inflammatory cytokines in COVID-19 patients.4,5 However, the mechanism of cytokine-induced lymphopenia in COVID-19 is very unclear. IL-2 is critical for the proliferation, differentiation, and function of T cells, including Tregs, CD4+, and CD8+ effector cells.6 Here, we reported the negative relationship between the concentration of soluble IL-2 receptor (sIL-2R) and T-cell number in blood from COVID-19 patients. In vitro addition of recombinant CD25 could inhibit the proliferation and function of T cells from PBMC after stimulated with TCR signaling, which could be rescued by strong IL-2 signaling. Our data suggested the importance of IL-2 signaling in lymphopenia of COVID-19 patients.

  • 原文来源：https://www.nature.com/articles/s41423-020-0484-x
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    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
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  • 《Nature，9月13日，Obesity is a potential risk factor contributing to clinical manifestations of COVID-19》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-09-16
    • Obesity is a potential risk factor contributing to clinical manifestations of COVID-19 Zhenyu Kang, Shanshan Luo, Yang Gui, Haifeng Zhou, Zili Zhang, Chunxia Tian, Qiaoli Zhou, Quansheng Wang, Yu Hu, Heng Fan & Desheng Hu International Journal of Obesity (2020) Abstract Background Since December 2019, novel coronavirus (SARS-CoV-2)-induced pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. COVID-19 patients demonstrated significantly different outcomes in clinic. We aimed to figure out whether obesity is a risk factor influencing the progression and prognosis of COVID-19. Methods 95 patients with COVID-19 were divided into obesity group and non-obesity group according to their body mass index (BMI). The demographic data, clinical characteristics, laboratory examination, and chest computed tomography (CT) were collected, analyzed and compared between two groups. Results Our data showed that COVID-19 patients with obesity had more underlying diseases and higher mortality rate compared to those without obesity. Furthermore, patients with obesity also demonstrated more severe pathological change in lung and higher blood lymphocytes, triglycerides, IL-6, CRP, cystatin C, alanine aminotransferase (ALT), erythrocyte sedimentation rate (ESR), which may greatly influence disease progression and poor prognosis of COVID-19.
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