Since the last revision of food Good Manufacturing Practices (GMPs) almost 20 years ago, the food manufacturing industry has seen many changes, including newly recognized pathogens, more sophisticated technologies, and increased automation. While GMPs can control for many food safety problems, it is not clear that current GMPs adequately address these new developments. The food safety literature reviewed for this study shows that there continue to be food safety problems. The Food and Drug Administration (FDA) is currently evaluating its food GMPs regulations to ensure that they take today's technologies and food safety hazards into account.