Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review
by Junxiong Pang 1,2,*,Min Xian Wang 1,2,Ian Yi Han Ang 1,Sharon Hui Xuan Tan 1,Ruth Frances Lewis 1,Jacinta I-Pei Chen 1,Ramona A Gutierrez 3,Sylvia Xiao Wei Gwee 1,2,Pearleen Ee Yong Chua 1,2,Qian Yang 1,Xian Yi Ng 1,Rowena KS Yap 1,Hao Yi Tan 1,Yik Ying Teo 1,Chorh Chuan Tan 4,Alex R. Cook 1,Jason Chin-Huat Yap 1 andLi Yang Hsu 1
1
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore
2
Centre for Infectious Disease Epidemiology and Research, National University of Singapore, Singapore 117549, Singapore
3
National Centre for Infectious Diseases, Singapore 308442, Singapore
4
Ministry of Health, Singapore 169854, Singapore
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(3), 623; https://doi.org/10.3390/jcm9030623
Received: 13 February 2020 / Revised: 17 February 2020 / Accepted: 19 February 2020 / Published: 26 February 2020
Abstract
Rapid diagnostics, vaccines and therapeutics are important interventions for the management of the 2019 novel coronavirus (2019-nCoV) outbreak. It is timely to systematically review the potential of these interventions, including those for Middle East respiratory syndrome-Coronavirus (MERS-CoV) and severe acute respiratory syndrome (SARS)-CoV, to guide policymakers globally on their prioritization of resources for research and development. A systematic search was carried out in three major electronic databases (PubMed, Embase and Cochrane Library) to identify published studies in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Supplementary strategies through Google Search and personal communications were used. A total of 27 studies fulfilled the criteria for review. Several laboratory protocols for confirmation of suspected 2019-nCoV cases using real-time reverse transcription polymerase chain reaction (RT-PCR) have been published.
