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《Science，7月3日，SARS-CoV-2 productively infects human gut enterocytes》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-07-07

  • SARS-CoV-2 productively infects human gut enterocytes
    Mart M. Lamers1,*, Joep Beumer2,*, Jelte van der Vaart2,*, Kèvin Knoops3, Jens Puschhof2, Tim I. Breugem1

    See all authors and affiliations

    Science  03 Jul 2020:
    Vol. 369, Issue 6499, pp. 50-54
    DOI: 10.1126/science.abc1669

    Abstract
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause coronavirus disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs with transmission through the respiratory route. However, clinical evidence suggests that the intestine may present another viral target organ. Indeed, the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) is highly expressed on differentiated enterocytes. In human small intestinal organoids (hSIOs), enterocytes were readily infected by SARS-CoV and SARS-CoV-2, as demonstrated by confocal and electron microscopy. Enterocytes produced infectious viral particles, whereas messenger RNA expression analysis of hSIOs revealed induction of a generic viral response program. Therefore, the intestinal epithelium supports SARS-CoV-2 replication, and hSIOs serve as an experimental model for coronavirus infection and biology.

  • 原文来源：https://science.sciencemag.org/content/369/6499/50
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  • 《Science，5月1日，SARS-CoV-2 productively infects human gut enterocytes》
    • 来源专题：COVID-19科研动态监测
    • 编译者：xuwenwhlib
    • 发布时间：2020-05-03
    • SARS-CoV-2 productively infects human gut enterocytes Mart M. Lamers1,*, Joep Beumer2,*, Jelte van der Vaart2,*, Kèvin Knoops3, Jens Puschhof2, Tim I. Breugem1, Raimond B. G. Ravelli3, J. Paul van Schayck3, Anna Z. Mykytyn1, Hans Q. Duimel3, Elly van Donselaar3, Samra Riesebosch1, Helma J. H. Kuijpers3, Debby Schippers1, Willine J. van de Wetering3, Miranda de Graaf1, Marion Koopmans1, Edwin Cuppen4,5, Peter J. Peters3, Bart L. Haagmans1,†, Hans Clevers2,†,‡ See all authors and affiliations Science 01 May 2020: eabc1669 DOI: 10.1126/science.abc1669 Abstract The virus severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) can cause coronavirus disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs with transmission via the respiratory route. However, clinical evidence suggests that the intestine may present another viral target organ. Indeed, the SARS-CoV-2 receptor angiotensin converting enzyme 2 (ACE2) is highly expressed on differentiated enterocytes. In human small intestinal organoids (hSIOs), enterocytes were readily infected by SARS-CoV and SARS-CoV-2 as demonstrated by confocal- and electron-microscopy. Consequently, significant titers of infectious viral particles were detected. mRNA expression analysis revealed strong induction of a generic viral response program. Hence, intestinal epithelium supports SARS-CoV-2 replication, and hSIOs serve as an experimental model for coronavirus infection and biology
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  • 《7月3日_SARS-CoV-2感染人肠道肠上皮细胞》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-07-07
    • 伊拉斯姆斯大学医学中心、荷兰皇家艺术和科学院、马斯特里赫特大学、乌得勒支大学医学中心和Hartwig医学基金会的科研人员7月3日在期刊Science在线发表题为“SARS-CoV-2 productively infects human gut enterocytes”的文章。 文章指出，SARS-CoV-2导致了COVID-19大流行，主要通过呼吸道途径感染肺部。然而，临床证据表明，肠道可能是病毒的另一种靶器官。事实上，SARS-CoV-2受体血管紧张素转换酶2 （ACE2）在分化的肠上皮细胞上高度表达。通过共聚焦和电子显微镜发现，在人小肠类器官（hSIOs）中，肠上皮细胞很容易被SARS-CoV和SARS-CoV-2感染。肠上皮细胞产生了感染性病毒颗粒，分析hSIOs信使RNA的表达可知其诱导了通用病毒的反应程序。因此，肠上皮细胞支持SARS-CoV-2复制，而hSIOs作为冠状病毒感染和生物学的实验模型。 4.附件： 原文链接：https://science.sciencemag.org/content/369/6499/50
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