《MedRixv,3月3日,Highly ACE2 Expression in Pancreas May Cause Pancreas Damage After SARS-CoV-2 Infection》

  • 来源专题:COVID-19科研动态监测
  • 编译者: zhangmin
  • 发布时间:2020-03-04
  • Highly ACE2 Expression in Pancreas May Cause Pancreas Damage After SARS-CoV-2 Infection

    Furong Liu, Xin Long, Wenbin Zou, Minghao Fang, Wenjuan Wu, Wei Li, Bixiang Zhang, Wanguang Zhang, Xiaoping Chen, Zhanguo Zhang

    doi: https://doi.org/10.1101/2020.02.28.20029181

    Abstract

    The ongoing outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started in the end of 2019 in China has triggered a global public health crisis. Previous studies have shown that SARS-CoV-2 infects cells by binding angiotensin-converting enzyme 2 (ACE2), which is the same as SARS-CoV. The expression and distribution of ACE2 in the pancreas are unknown.

    *注,本文为预印本论文手稿,是未经同行评审的初步报告,其观点仅供科研同行交流,并不是结论性内容,请使用者谨慎使用.

  • 原文来源:https://www.medrxiv.org/content/10.1101/2020.02.28.20029181v1
相关报告
  • 《MedRixv,2月13日,ACE2 Expression in Kidney and Testis May Cause Kidney and Testis Damage After 2019-nCoV Infection》

    • 来源专题:COVID-19科研动态监测
    • 编译者:zhangmin
    • 发布时间:2020-02-14
    • ACE2 Expression in Kidney and Testis May Cause Kidney and Testis Damage After 2019-nCoV Infection Caibin Fan, Kai Li, Yanhong Ding, Wei Lu Lu, Jianqing Wang doi: https://doi.org/10.1101/2020.02.12.20022418 Abstract In December 2019 and January 2020, novel coronavirus (2019-nCoV) - infected pneumonia (NCIP) occurred in Wuhan, and has already posed a serious threat to public health. ACE2 (Angiotensin Converting Enzyme 2) has been shown to be one of the major receptors that mediate the entry of 2019-nCoV into human cells, which also happens in severe acute respiratory syndrome coronavirus (SARS). Several researches have indicated that some patients have abnormal renal function or even kidney damage in addition to injury in respiratory system, and the related mechanism is unknown. This arouses our interest in whether coronavirus infection will affect the urinary and male reproductive systems. Here in this study, we used the online datasets to analyze ACE2 expression in different human organs. The results indicate that ACE2 highly expresses in renal tubular cells, Leydig cells and cells in seminiferous ducts in testis. Therefore, virus might directly bind to such ACE2 positive cells and damage the kidney and testicular tissue of patients. Our results indicate that renal function evaluation and special care should be performed in 2019-nCoV patients during clinical work, because of the kidney damage caused by virus and antiviral drugs with certain renal toxicity. In addition, due to the potential pathogenicity of the virus to testicular tissues, clinicians should pay attention to the risk of testicular lesions in patients during hospitalization and later clinical follow-up, especially the assessment and appropriate intervention in young patients' fertility. *注,本文为预印本论文手稿,是未经同行评审的初步报告,其观点仅供科研同行交流,并不是结论性内容,请使用者谨慎使用.
  • 《3月3日_胰腺中ACE2表达高可能导致SARS-CoV-2感染后的胰腺损伤》

    • 来源专题:COVID-19科研动态监测
    • 编译者:zhangmin
    • 发布时间:2020-03-05
    • 1.时间:2020年3月3日 2.机构或团队:华中科技大学同济医学院附属同济医院、金银潭医院 3.事件概要: 3月3日,medRxiv预印本平台发表了来自华中科技大学同济医学院附属同济医院和金银潭医院研究团队的题为“Highly ACE2 Expression in Pancreas May Cause Pancreas Damage After SARS-CoV-2 Infection”的文章。 文章指出,先前的研究表明SARS-CoV-2通过结合ACE2酶感染细胞,然而胰腺中ACE2的表达和分布尚不清楚,SARS-CoV-2感染后胰腺的损伤有待研究。该文章收集了公共数据(大量RNA-seq和单细胞RNA-seq数据)来分析ACE2酶在胰腺(外分泌腺和胰岛中)的表达和分布。该文章指出包括轻度和重度COVID-19患者在内的临床数据表明存在轻度胰腺炎。文章指出,在67例严重病例中,有11例患者(16.41%)的淀粉酶和脂肪酶水平升高,5例患者(7.46%)则存在影像学病变。在54例轻度病例中,只有一名患者(1.85%)显示淀粉酶和脂肪酶水平升高,但没有影像学病变。文章指出,该研究揭示了COVID-19患者轻度胰腺损伤的现象和可能的原因,建议SARS-CoV-2感染后的胰腺炎也应在临床工作中予以重视。 *注,本文为预印本论文手稿,是未经同行评审的初步报告,其观点仅供科研同行交流,并不是结论性内容,请使用者谨慎使用。 4.附件: 原文链接https://www.medrxiv.org/content/10.1101/2020.02.28.20029181v1