登录
 机构网站
  1. 首页
  2. 情报产品
  3. 快讯详情

《Nature，4月10日，Toothbrushing against coronavirus》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-04-10

  • Toothbrushing against coronavirus

    M. Addy

    British Dental Journal volume 228, page487(2020)

    Sir, hand washing with soap or antimicrobial gels to reduce the transmission of infectious diseases, including COVID-19, is based on sound biological principles. Thus, soaps, detergents and antiseptics can destroy or remove a range of infectious microbes from the hands, thereby reducing the risk of indirect self or person to person infection. COVID-19 is a respiratory infection, where transmission between individuals is primarily by droplet spread of the coronavirus by coughing or sneezing. From my own knowledge and listening to experts, a major source of droplets are derived from saliva.

  • 原文来源：https://www.nature.com/articles/s41415-020-1450-9
9浏览量
原文链接
相关报告

  • 《Nature，4月8日，Pandemic data challenges》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-04-09
    • Pandemic data challenges Nature Machine Intelligence (2020) The worldwide outbreak of COVID-19 has led to great tragedy and poses unprecedented challenges for countries’ healthcare systems. Data has become an important instrument in the global fight against the unprecedented spread of the virus. But how will we ensure a return to previous forms of data privacy once the pandemic subsides? In a bid to help curb a disastrous course of the disease, scientists are coming together to share research findings and data as quickly and collaboratively as possible. Immediate goals are to understand what measures can slow the spread of COVID-19, which people are the most vulnerable and how to treat critical patients under challenging circumstances. In the medium term, data-driven approaches can help crack the virus’s biology to develop and test vaccines.
    57浏览量
    原文链接

  • 《Nature，8月4日，Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-08-19
    • Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation Matthew McCallum, Alexandra C. Walls, John E. Bowen, Davide Corti & David Veesler Nature Structural & Molecular Biology (2020) Abstract SARS-CoV-2 is the causative agent of the COVID-19 pandemic, with 10 million infections and more than 500,000 fatalities by June 2020. To initiate infection, the SARS-CoV-2 spike (S) glycoprotein promotes attachment to the host cell surface and fusion of the viral and host membranes. Prefusion SARS-CoV-2 S is the main target of neutralizing antibodies and the focus of vaccine design. However, its limited stability and conformational dynamics are limiting factors for developing countermeasures against this virus. We report here the design of a construct corresponding to the prefusion SARS-CoV-2 S ectodomain trimer, covalently stabilized by a disulfide bond in the closed conformation. Structural and antigenicity analyses show we successfully shut S in the closed state without otherwise altering its architecture. We demonstrate that this strategy is applicable to other β-coronaviruses, such as SARS-CoV and MERS-CoV, and might become an important tool for structural biology, serology, vaccine design and immunology studies.
    13浏览量
    原文链接