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《Cell Host & Microbe，3月23日，Infection and Rapid Transmission of SARS-CoV-2 in Ferrets》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-03-31

  • Abstract

    The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China and rapidly spread worldwide. Toprevent SARS-CoV-2 dissemination, understanding the in vivo characteristics of SARS-CoV2 is a high priority. We report a ferret model of SARS-CoV-2 infection and transmission thatrecapitulates aspects of human disease. SARS-CoV-2-infected ferrets exhibit elevated bodytemperatures and virus replication. Although fatalities were not observed, SARS-CoV-2-infected ferrets shed virus in nasal washes, saliva, urine and feces up to 8 days post infection. At 2 days post-contact, SARS-CoV-2 was detected in all naïve direct contactferrets. Furthermore, a few naïve indirect contact ferrets were positive for viral RNA,suggesting airborne transmission.

  • 原文来源：https://els-jbs-prod-cdn.jbs.elsevierhealth.com/pb-assets/journals/research/cell-host-microbe/PDFs/chom_2285_preproof-1585580136920.pdf
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