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《BioRxiv，3月3日，Multi-epitope vaccine design using an immunoinformatics approach for 2019 novel coronavirus in China (SARS-CoV-2)》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-03-04

  • Multi-epitope vaccine design using an immunoinformatics approach for 2019 novel coronavirus in China (SARS-CoV-2)

    Ye Feng, Min Qiu, Shengmei Zou, Yun Li, Kai Luo, Rongchang Chen, Yingqiang Sun, Kui Wang, Xinlei Zhuang, Shanshan Zhang, Shuqing Chen, Fan Mo

    doi: https://doi.org/10.1101/2020.03.03.962332

    Abstract

    A new coronavirus SARS-CoV-2, recently discovered in Wuhan, China, has caused over 74000 infection cases and 2000 deaths. Due to the rapidly growing cases and the unavailability of specific therapy, there is a desperate need for vaccines to combat the epidemic of SARS-CoV-2. In the present study, we performed an in silico approach based on the available virus genome to identify the antigenic B-cell epitopes and human-leukocyte-antigen (HLA) restricted T-cell epitopes. A total of 61 B-cell epitopes were initially identified, 19 of which with higher potential immunogenicity were used for vaccine design.

    *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.

  • 原文来源：https://www.biorxiv.org/content/10.1101/2020.03.03.962332v1
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