Imaging of gene expression in live cells or tissues has largely relied on light-based strategies detecting fluorescence or luminescence, but poor transmission of light through tissues limits the depth that can be imaged. A new study reports a synthetic biology approach to encode an ultrasound-based gene expression reporter that is applicable to mammalian cells in vitro and in vivo. Credit: Chnit Siri Kan Ti N Cheiynghim/EyeEm/Getty To adopt ultrasound as a robust biomolecular readout, strategie...
