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《Nature，4月23日，SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-04-24

  • SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

    Waradon Sungnak, Ni Huang, Christophe Bécavin, Marijn Berg, Rachel Queen, Monika Litvinukova, Carlos Talavera-López, Henrike Maatz, Daniel Reichart, Fotios Sampaziotis, Kaylee B. Worlock, Masahiro Yoshida, Josephine L. Barnes & HCA Lung Biological Network

    Nature Medicine (2020)

    Abstract

    We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.

  • 原文来源：https://www.nature.com/articles/s41591-020-0868-6
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    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-06-24
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  • 《4月23日_SARS-CoV-2进入因子与先天免疫基因在鼻上皮细胞中协同高表达》
    • 来源专题：COVID-19科研动态监测
    • 编译者：xuwenwhlib
    • 发布时间：2020-04-25
    • 信息名称：SARS-CoV-2进入因子与先天免疫基因在鼻上皮细胞中协同高表达 1.时间：2020年4月23日 2.机构或团队：美国翻译基因组学研究院（Translational Genomics Research Institute，TGen） 3.事件概要： 美国翻译基因组学研究院联合多家机构在Nature Medicine发表文章“SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes”。文章旨在通过对各个组织进行单细胞RNA测序以解释SARS-CoV-2传播的高效率。 文章基于单细胞RNA测序技术，比较正常人和COVID-19感染患者的呼吸道、角膜和肠上皮细胞组织中与SARS-CoV-2进入宿主相关的基因。研究发现，这些与进入宿主相关的基因与固有免疫基因在这些组织中协同共表达，在初始病毒感染、传播和清除中的发挥潜在作用。 4.附件： 原文链接：https://www.nature.com/articles/s41591-020-0868-6
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