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《bioRxiv，6月9日，Structural basis of a public antibody response to SARS-CoV-2》

  • 来源专题：COVID-19科研动态监测
  • 编译者： xuwenwhlib
  • 发布时间：2020-06-10

  • Structural basis of a public antibody response to SARS-CoV-2
    View ORCID ProfileMeng Yuan, Hejun Liu,  View ORCID ProfileNicholas C. Wu,  View ORCID ProfileChang-Chun D. Lee,  View ORCID ProfileXueyong Zhu,  View ORCID ProfileFangzhu Zhao,  View ORCID ProfileDeli Huang, Wenli Yu, Yuanzi Hua, Henry Tien, Thomas F. Rogers, Elise Landais, Devin Sok, Joseph G. Jardine, Dennis R. Burton, Ian A. Wilson
    doi: https://doi.org/10.1101/2020.06.08.141267

    Abstract
    Molecular-level understanding of human neutralizing antibody responses to SARS-CoV-2 could accelerate vaccine design and facilitate drug discovery. We analyzed 294 SARS-CoV-2 antibodies and found that IGHV3-53 is the most frequently used IGHV gene for targeting the receptor binding domain (RBD) of the spike (S) protein. We determined crystal structures of two IGHV3-53 neutralizing antibodies +/- Fab CR3022 ranging from 2.33- to 3.11-angstrom resolution. The germline-encoded residues of IGHV3-53 dominate binding to the ACE2 binding site epitope with no overlap with the CR3022 epitope. Moreover, IGHV3-53 is used in combination with a very short CDR H3 and different light chains. Overall, IGHV3-53 represents a versatile public VH in neutralizing SARS-CoV-2 antibodies, where their specific germline features and minimal affinity maturation provide important insights for vaccine design and assessing outcomes.

  • 原文来源：https://www.biorxiv.org/content/10.1101/2020.06.08.141267v1
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    • 来源专题：COVID-19科研动态监测
    • 编译者：xuwenwhlib
    • 发布时间：2020-06-03
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  • 《Science，7月13日，Structural basis of a shared antibody response to SARS-CoV-2》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-07-28
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