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《MedRxiv，3月20日，Antibody responses to SARS-CoV-2 in COVID-19 patients: the perspective application of serological tests in clinical practice》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-03-22

  • Antibody responses to SARS-CoV-2 in COVID-19 patients: the perspective application of serological tests in clinical practice

    Quan-xin Long, Hai-jun Deng, Juan Chen, Jieli Hu, Bei-zhong Liu, Pu Liao, Yong Lin, Li-hua Yu, Zhan Mo, Yin-yin Xu, Fang Gong, Gui-cheng Wu, Xian-xiang Zhang, Yao-kai Chen, Zhi-jie Li, Kun Wang, Xiao-li Zhang, Wen-guang Tian, Chang-chun Niu, Qing-jun Yang, Jiang-lin Xiang, Hong-xin Du, Hua-wen Liu, Chunhui Lang, Xiao-he Luo, Shao-bo Wu, Xiao-ping Cui, Zheng Zhou, Jing Wang, Cheng-jun Xue, Xiao-feng Li, Li Wang, Xiao-jun Tang, Yong Zhang, Jing-fu Qiu, Xia-mao Liu, Jin-jing Li, De-chun Zhang, Fan Zhang, Xue-fei Cai, Deqiang Wang, Yuan Hu, Ji-hua Ren, Ni Tang, Ping Liu, Qin Li, Ai-long Huang

    doi: https://doi.org/10.1101/2020.03.18.20038018

    Abstract

    Background We aim to investigate the profile of acute antibody response in COVID-19 patients, and provide proposals for the usage of antibody test in clinical practice. Methods A multi-center cross-section study (285 patients) and a single-center follow-up study (63 patients) were performed to investigate the feature of acute antibody response to SARS-CoV-2. A cohort of 52 COVID-19 suspects and 64 close contacts were enrolled to evaluate the potentiality of the antibody test. Results The positive rate for IgG reached 100% around 20 days after symptoms onset. The median day of serocon-version for both lgG and IgM was 13 days after symptoms onset.

    *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.

  • 原文来源：https://www.medrxiv.org/content/10.1101/2020.03.18.20038018v1
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