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《Cell，11月23日，Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-12-22

  • Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19
    Lauren B. Rodda 7
    Jason Netland 7
    Laila Shehata 8
    Daniel J. Campbell
    David J. Rawlings
    Marion Peppe

    Published:November 23, 2020DOI:https://doi.org/10.1016/j.cell.2020.11.029
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    Summary
    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is causing a global pandemic, and cases continue to rise. Most infected individuals experience mildly symptomatic coronavirus disease 2019 (COVID-19), but it is unknown whether this can induce persistent immune memory that could contribute to immunity. We performed a longitudinal assessment of individuals recovered from mild COVID-19 to determine whether they develop and sustain multifaceted SARS-CoV-2-specific immunological memory. Recovered individuals developed SARS-CoV-2-specific immunoglobulin (IgG) antibodies, neutralizing plasma, and memory B and memory T cells that persisted for at least 3 months. Our data further reveal that SARS-CoV-2-specific IgG memory B cells increased over time. Additionally, SARS-CoV-2-specific memory lymphocytes exhibited characteristics associated with potent antiviral function: memory T cells secreted cytokines and expanded upon antigen re-encounter, whereas memory B cells expressed receptors capable of neutralizing virus when expressed as monoclonal antibodies. Therefore, mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks of antiviral immunity.

  • 原文来源：https://www.cell.com/cell/fulltext/S0092-8674(20)31565-8
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    • 编译者：zhangmin
    • 发布时间：2021-02-25
    • Maturation and persistence of the anti-SARS-CoV-2 memory B cell response Aurélien Sokal 18 Pascal Chappert 18 Giovanna Barba-Spaeth 19 Jean-Claude Weill 17 Claude-Agnès Reynaud 17 Matthieu Mahévas 17, 20 Show all authors Show footnotes Published:February 02, 2021DOI:https://doi.org/10.1016/j.cell.2021.01.050 Summary Memory B cells play a fundamental role in host defenses against viruses, but to date, their role has been relatively unsettled in the context of SARS-CoV-2. We report here a longitudinal single-cell and repertoire profiling of the B cell response up to 6 months in mild and severe COVID-19 patients. Distinct SARS-CoV-2 spike-specific activated B cell clones fueled an early antibody-secreting cell burst as well as a durable synchronous germinal center response. While highly mutated memory B cells, including pre-existing cross-reactive seasonal Betacoronavirus-specific clones, were recruited early in the response, neutralizing SARS-CoV-2 RBD-specific clones accumulated with time and largely contributed to the late, remarkably stable, memory B cell pool. Highlighting germinal center maturation, these cells displayed clear accumulation of somatic mutations in their variable region genes over time. Overall, these findings demonstrate that an antigen-driven activation persisted and matured up to 6 months after SARS-CoV-2 infection and may provide long-term protection.
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