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《LANCET，5月7日，Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures》

  • 来源专题：COVID-19科研动态监测
  • 编译者： xuwenwhlib
  • 发布时间：2020-05-08

  • Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures

    Kenrie P Y Hui, PhD

    Man-Chun Cheung, MSc

    Ranawaka A P M Perera, PhD

    Ka-Chun Ng, BSc

    Christine H T Bui, PhD

    John C W Ho, PhD

    Published:May 07, 2020DOI:https://doi.org/10.1016/S2213-2600(20)30193-4

    Background

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019, causing a respiratory disease (coronavirus disease 2019, COVID-19) of varying severity in Wuhan, China, and subsequently leading to a pandemic. The transmissibility and pathogenesis of SARS-CoV-2 remain poorly understood. We evaluate its tissue and cellular tropism in human respiratory tract, conjunctiva, and innate immune responses in comparison with other coronavirus and influenza virus to provide insights into COVID-19 pathogenesis.

  • 原文来源：https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30193-4/fulltext
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