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《Nature，12月24日，Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2021-02-01

  • Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19

    Hong-Yi Zheng, Min Xu, Cui-Xian Yang, Ren-Rong Tian, Mi Zhang, Jian-Jian Li, Xi-Cheng Wang, Zhao-Li Ding, Gui-Mei Li, Xiao-Lu Li, Yu-Qi He, Xing-Qi Dong, Yong-Gang Yao & Yong-Tang Zheng

    Signal Transduction and Targeted Therapy volume 5, Article number: 294 (2020)

    Abstract

    Understanding the processes of immune regulation in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for improving treatment. Here, we performed longitudinal whole-transcriptome RNA sequencing on peripheral blood mononuclear cell (PBMC) samples from 18 patients with coronavirus disease 2019 (COVID-19) during their treatment, convalescence, and rehabilitation. After analyzing the regulatory networks of differentially expressed messenger RNAs (mRNAs), microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) between the different clinical stages, we found that humoral immunity and type I interferon response were significantly downregulated, while robust T-cell activation and differentiation at the whole transcriptome level constituted the main events that occurred during recovery from COVID-19. The formation of this T cell immune response might be driven by the activation of activating protein-1 (AP-1) related signaling pathway and was weakly affected by other clinical features. These findings uncovered the dynamic pattern of immune responses and indicated the key role of T cell immunity in the creation of immune protection against this disease.

  • 原文来源：https://www.nature.com/articles/s41392-020-00457-4
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