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《Nature，6月16日，Risk factors for death in 1859 subjects with COVID-19》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-06-17

  • Risk factors for death in 1859 subjects with COVID-19

    Lei Chen, Jianming Yu, Wenjuan He, Li Chen, Guolin Yuan, Fang Dong, Wenlan Chen, Yulin Cao, Jingyan Yang, Liling Cai, Di Wu, Qijie Ran, Lei Li, Qiaomei Liu, Wenxiang Ren, Fei Gao, Hongxiang Wang, Zhichao Chen, Robert Peter Gale, Qiubai Li & Yu Hu

    Leukemia (2020)

    Abstract

    We studied 1859 subjects with confirmed COVID-19 from seven centers in Wuhan 1651 of whom recovered and 208 died. We interrogated diverse covariates for correlations with risk of death from COVID-19. In multi-variable Cox regression analyses increased hazards of in-hospital death were associated with several admission covariates: (1) older age (HR = 1.04; 95% Confidence Interval [CI], 1.03, 1.06 per year increase; P < 0.001); (2) smoking (HR = 1.84 [1.17, 2.92]; P = 0.009); (3) admission temperature per °C increase (HR = 1.32 [1.07, 1.64]; P = 0.009); (4) Log10 neutrophil-to-lymphocyte ratio (NLR; HR = 3.30 [2.10, 5.19]; P < 0.001); (5) platelets per 10 E + 9/L decrease (HR = 0.996 [0.994, 0.998]; P = 0.001); (6) activated partial thromboplastin (aPTT) per second increase (HR = 1.04 [1.02, 1.05]; P < 0.001); (7) Log10 D-dimer per mg/l increase (HR = 3.00 [2.17, 4.16]; P < 0.001); and (8) Log10 serum creatinine per μmol/L increase (HR = 4.55 [2.72, 7.62]; P < 0.001). In piecewise linear regression analyses Log10NLR the interval from ≥0.4 to ≤1.0 was significantly associated with an increased risk of death. Our data identify covariates associated with risk of in hospital death in persons with COVID-19.

  • 原文来源：https://www.nature.com/articles/s41375-020-0911-0
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