An overview of Human Immunodeficiency Virus (HIV) Infection. Human Immunodeficiency Virus (HIV) presents a complex knot for scientists to unravel. After initial contact and attachment to a cell of the immune system (e.g. lymphocytes, monocytes), there is a cascade of intracellular events. The endproduct of these events is the production of massive numbers of new viral particles, death of the infected cells, and ultimate devastation of the immune system.