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《Science，8月11日，Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-08-19

  • Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

    View ORCID ProfilePrabhu S. Arunachalam1,*, View ORCID ProfileFlorian Wimmers1,*, View ORCID ProfileChris Ka Pun Mok2,*, View ORCID ProfileRanawaka A. P. M. Perera3,*, View ORCID ProfileMadelein

    See all authors and affiliations

    Science 11 Aug 2020:

    eabc6261

    DOI: 10.1126/science.abc6261

    Abstract

    COVID-19 represents a global crisis, yet major knowledge gaps remain about human immunity to SARS-CoV-2. We analyzed immune responses in 76 COVID-19 patients and 69 healthy individuals from Hong Kong and Atlanta. In PBMCs of COVID-19 patients, there was reduced expression of HLA-DR and pro-inflammatory cytokines by myeloid cells, and impaired mTOR-signaling and IFN-α production by plasmacytoid DCs. In contrast, there were enhanced plasma levels of inflammatory mediators, including EN-RAGE, TNFSF14, and oncostatin-M, which correlated with disease severity and increased bacterial products in human plasma. Single-cell transcriptomics revealed no type-I IFN, reduced HLA-DR in myeloid cells of severe patients, and transient expression of IFN-stimulated genes. This was consistent with bulk PBMC transcriptomics, and transient, low plasma IFN-α levels during infection. These results reveal mechanisms and potential therapeutic targets for COVID-19.

     

  • 原文来源：https://science.sciencemag.org/content/early/2020/08/10/science.abc6261
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