Trends in clinical features of novel coronavirus disease (COVID-19): A systematic review and meta-analysis of studies published from December 2019 to February 2020
Author links open overlay panelToshieManabeaHiroyasuAkatsubKazuhikoKotaniaKoichiroKudocd
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https://doi.org/10.1016/j.resinv.2020.05.005
Abstract
Background
Since novel coronavirus disease (COVID-19) emerged, various clinical features of COVID-19 have been reported.
Methods
We conducted a systematic review of published studies reporting the clinical features of COVID-19. Two investigators independently searched PubMed (December 2019–February 2020) for eligible articles. A meta-analysis was performed to measure the frequencies of clinical outcomes and symptoms of COVID-19. A stratified analysis was conducted according to the timeline of outbreak and exposure histories: Group I, most patients were exposed to the Hunan seafood wholesale market and lived in Wuhan, Hubei province; Group II, patients lived in Hubei province but were not directly exposed to the market; and Group III, patients lived outside Hubei.
