Phylogenomic analysis of the 2019-nCoV coronavirus
Carmine Ceraolo, Federico M Giorgi
doi: https://doi.org/10.1101/2020.02.02.931162
Abstract
There is rising global concern for the recently emerged novel Coronavirus (2019-nCov). Full genomic sequences have been released by the worldwide scientific community in the last few weeks in order to understand the evolutionary origin and molecular characteristics of this virus. Taking advantage of all the genomic information currently available, we constructed a phylogenetic tree including also representatives of other coronaviridae, such as Bat coronavirus (BCoV) and SARS. We identified specific BCoV genomes which appear to be the closest relative to the new virus, with protein sequence identity of 91.1%, providing further evidence for a zoonotic origin of 2019-nCoV. We also detected low variability within the available 2019-nCoV specimens sequenced so far, despite a few hyper-variable genomic hotspots. Finally, we perform a full proteomic comparison with other coronaviridae, identifying key aminoacidic differences to model anti-viral strategies on.
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