登录
 机构网站
  1. 首页
  2. 情报产品
  3. 快讯详情

《MICROBES INFECT，2月2日，Is COVID-19 Receiving ADE From Other Coronaviruses?》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-02-22

  • Is COVID-19 Receiving ADE From Other Coronaviruses?

    Author links open overlay panelJason A.Tetro

    Show more

    https://doi.org/10.1016/j.micinf.2020.02.006

    Abstract

    One of the most perplexing questions regarding the current COVID-19 coronavirus epidemic is the discrepancy between the severity of cases observed in the Hubei province of China and those occurring elsewhere in the world. One possible answer is antibody dependent enhancement (ADE) of SARS-CoV-2 due to prior exposure to other coronaviruses. ADE modulates the immune response and can elicit sustained inflammation, lymphopenia, and/or cytokine storm, one or all of which have been documented in severe cases and deaths. ADE also requires prior exposure to similar antigenic epitopes, presumably circulating in local viruses, making it a possible explanation for the observed geographic limitation of severe cases and deaths.

  • 原文来源：https://www.sciencedirect.com/science/article/abs/pii/S1286457920300344
13浏览量
原文链接
相关报告

  • 《Science Advances，2月3日，A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2021-02-25
    • A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood Dianna L. Ng1,2,*, View ORCID ProfileAndrea C. Granados2,3,*, Yale A. Santos2,3,*, View ORCID ProfileVenice Servellita2,3,*, View ORCID ProfileGregory M. Goldgof2,... Science Advances  03 Feb 2021: Vol. 7, no. 6, eabe5984 DOI: 10.1126/sciadv.abe5984 Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease-19 (COVID-19), has emerged as the cause of a global pandemic. We used RNA sequencing to analyze 286 nasopharyngeal (NP) swab and 53 whole-blood (WB) samples from 333 patients with COVID-19 and controls. Overall, a muted immune response was observed in COVID-19 relative to other infections (influenza, other seasonal coronaviruses, and bacterial sepsis), with paradoxical down-regulation of several key differentially expressed genes. Hospitalized patients and outpatients exhibited up-regulation of interferon-associated pathways, although heightened and more robust inflammatory responses were observed in hospitalized patients with more clinically severe illness. Two-layer machine learning–based host classifiers consisting of complete (>1000 genes), medium (<100), and small (<20) gene biomarker panels identified COVID-19 disease with 85.1–86.5% accuracy when benchmarked using an independent test set. SARS-CoV-2 infection has a distinct biosignature that differs between NP swabs and WB and can be leveraged for COVID-19 diagnosis.  
    90浏览量
    原文链接

  • 《MICROBES INFECT，3月19日，Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-03-20
    • Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2 YeQiu1Yuan-BoZhao1QiongWangJin-YanLiZhi-JianZhouCe-HengLiaoXing-YiGe Show more https://doi.org/10.1016/j.micinf.2020.03.003 Abstract SARS-CoV-2, the newly identified human coronavirus causing severe pneumonia epidemic, was probably originated from Chinese horseshoe bats. However, direct transmission of the virus from bats to humans is unlikely due to lack of direct contact, implying the existence of unknown intermediate hosts. Angiotensin converting enzyme 2 (ACE2) is the receptor of SARS-CoV-2, but only ACE2s of certain species can be utilized by SARS-CoV-2. Here, we evaluated and ranked the receptor-utilizing capability of ACE2s from various species by phylogenetic clustering and sequence alignment with the currently known ACE2s utilized by SARS-CoV-2. As a result, we predicted that SARS-CoV-2 tends to utilize ACE2s of various mammals, except murines, and some birds, such as pigeon. This prediction may help to screen the intermediate hosts of SARS-CoV-2.
    150浏览量
    原文链接