Human Kidney is a Target for Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection
Bo Diao, Zeqing Feng, Chenhui Wang, Huiming Wang, Liang Liu, Changsong Wang, Rongshuai Wang, Ying Liu, Yueping Liu, Gang Wang, Zilin Yuan, Yuzhang Wu, Yongwen Chen
doi: https://doi.org/10.1101/2020.03.04.20031120
Abstract
BACKGROUND The coronavirus disease 2019 (COVID-19) is a newly emerged infection from the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Apart from the respiratory system, it is unclear whether SARS-CoV-2 can also directly infect other tissues such as the kidney or induce acute renal failure. METHODS We conducted a retrospective analysis of estimated glomerular filtration rate (eGFR), plasma creatinine, and urea concentrations along with other clinical parameters from 85 patients with laboratory-confirmed COVID-19 admitted to a hospital in Wuhan from January 17, 2020 to March 3, 2020.
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