The Impact of Host-Based Early Warning on Disease Outbreaks
Mark Hernandez, Lauren E Milechin, Shakti K Davis, Rich DeLaura, Kajal T Claypool, Albert Swiston
doi: https://doi.org/10.1101/2020.03.06.20029793
Abstract
Objective: The detection of communicable pathogens responsible for major outbreaks relies on health care professionals recognition of symptoms manifesting in infectious individuals. Early warning of such communicable diseases before the onset of symptoms could improve both patient care and public health responses. However, the potential impact of such a host-based early warning system on containing the spread of an outbreak and in steering public health response is unknown. Methods: We extend the deterministic SEIR (Susceptible, Exposed, Infectious, Recovered) model to simulate disease outbreak scenarios and to quantify the potential impact of a host-based early warning capability to mitigate pathogen transmission during an outbreak.
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