Prevalence of Gastrointestinal Symptoms and Fecal Viral Shedding in Patients With Coronavirus Disease 2019
A Systematic Review and Meta-analysis
Sravanthi Parasa, MD1; Madhav Desai, MD, MPH2; Viveksandeep Thoguluva Chandrasekar, MD3; et al Harsh K. Patel, MD4; Kevin F. Kennedy, MS5; Thomas Roesch, MD6; Marco Spadaccini, MD7; Matteo Colombo, MD7; Roberto Gabbiadini, MD7; Everson L. A. Artifon, MD8; Alessandro Repici, MD7; Prateek Sharma, MD2
Author Affiliations Article Information
JAMA Netw Open. 2020;3(6):e2011335. doi:10.1001/jamanetworkopen.2020.11335
Abstract
Importance Coronavirus disease 2019 (COVID-19) is a global pandemic and can involve the gastrointestinal (GI) tract, including symptoms like diarrhea and shedding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in feces.
Objective To provide a pooled estimate of GI symptoms, liver enzyme levels outside reference ranges, and fecal tests positive for SARS-CoV-2 among patients with COVID-19.
Data Sources An electronic literature search was performed for published (using MEDLINE/PubMed and Embase) and preprint (using bioRxiv and medRxiv) studies of interest conducted from November 1, 2019, to March 30, 2020. Search terms included “COVID-19,” “SARS-Cov-2,” and/or “novel coronavirus.”