《Nature，2月25日，Time to use the p-word? Coronavirus enters dangerous new phase》
来源专题：COVID-19科研动态监测
编译者：zhangmin
发布时间：2020-02-26
The spread of the new coronavirus could soon become unstoppable, say scientists who are concerned about a rapid surge in the number and size of outbreaks outside China. Some are even muttering the p-word: pandemic.
BEIJING – China will kickstart a phase III trial Feb. 3 to determine whether patients with 2019-nCoV can be treated with Gilead Sciences Inc.’s NUC inhibitor, remdesivir, which was originally developed for Ebola, four days after a U.S. patient was said to have recovered by using the drug candidate.
The study, expected to be completed on April 27, is a phase III randomized, double-blind, placebo-controlled multicenter study to evaluate the efficacy and safety of remdesivir in hospitalized adult patients with mild and moderate 2019-nCoV infections. It will enroll 270 patients and be carried out in the China-Japan Friendship Hospital in Beijing.
Gilead said it is expediting the laboratory testing of remdesivir against 2019-nCoV samples and working with the Chinese authorities.
Remdesivir is being developed by the U.S. company as a monophosphoramidate prodrug of code GS-441524 that targets viral RNA-dependent RNA polymerase. It was intended to be an intravenous treatment for Ebola, but it also showed potential against coronavirus and Nipah virus infections.
1.时间：2020年2月25日
2.信息来源：Nature
3.事件概要：
2月25日，Nature发布新闻（“Time to use the p-word? Coronavirus enters dangerous new phase”）称，随着疫情在全球迅速扩散，科学家担心COVID-19可能很快会成为大流行病（即p-word: pandemic，疫情在多个地区无限制传播）。该问题尚在讨论中。目前，世卫组织基于中国的感染率峰值和控制措施等因素，认为应推迟将疫情定性“大流行”的决定。
4.附件：
原文链接：https://www.nature.com/articles/d41586-020-00551-1
