《Classification and treatment approach of chemical burn associated Limbal stem cell deficiency: based on novel global consensus》

  • 来源专题:再生医学与脑科学
  • 编译者: 蒋君
  • 发布时间:2025-02-13
  • 目的: 根据新的全球共识分类评估化学烧伤诱导的角膜缘干细胞缺陷 (LSCD) 的严重程度分布,并比较全球共识前后的治疗方法。

    方法: 包括 109 例 LSCD 患者的 127 只眼的病历。LSCD 分期根据 “International LSCD Working Group” 发布的全球共识分类进行分类。

    结果: 平均年龄为 37.5 ± 16.5 (6-75)。根据全球共识量表,LSCD 分期分布如下: 5 只眼 (3.9%) 1A 期;16 只眼 (12.6%) 1B 期;4 只眼 1C 期 (3.2%);15 只眼 (11.8%) 的 2A 期;36 只眼 (28.3%) 2B 期;51 只眼 (40.2%) 为 3 期。共有 88 只眼 (69.3%) 接受了 LSCD 手术。其中,80 例在全球共识发布前 (2020 年 10 月之前) 接受过手术,58 例 (72.5%) 术前患有重度 (≥ 2B 期) LSCD,22 例 (27.5%) 患有术前早期 (≤ 2A 期) LSCD。截至 2020 年 10 月,所有接受手术的 8 只眼都患有全球共识推荐的术前重度 (≥ 2B 期) LSCD。

    结论: 最近,关于 LSCD 的分类和管理已经达成了全球共识。这项研究是最早根据全球共识提供关于 LSCD 严重程度分布的小规模流行病学数据的研究之一。据观察,根据这一新共识,27.5% 的不推荐手术的眼睛进行了手术。随着对这一共识的认识不断提高,有可能避免不必要的手术干预。

  • 原文来源:https://pubmed.ncbi.nlm.nih.gov/39853616/
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