Epitope-based peptide vaccines predicted against novel coronavirus disease caused by SARS-CoV-2
Lin Li, Ting Sun, YuFei He, Wendong Li, Yubo Fan, Jing Zhang
doi: https://doi.org/10.1101/2020.02.25.965434
Abstract
The outbreak of the 2019 novel coronavirus (SARS-CoV-2) has infected thousands of people with a large number of deaths across 26 countries. The sudden appearance of the virus leads to the limited existing therapies for SARS-CoV-2. Therefore, vaccines and antiviral medicines are in desperate need. This study took immune-informatics approaches to identify B- and T-cell epitopes for surface glycoprotein (S) of SARS-CoV-2, followed by estimating their antigenicity and interactions with the human leukocyte antigen (HLA) alleles.
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