《JAMA,9月25日,Susceptibility to SARS-CoV-2 Infection Among Children and Adolescents Compared With Adults A Systematic Review and Meta-analysis》

  • 来源专题:COVID-19科研动态监测
  • 编译者: zhangmin
  • 发布时间:2020-10-14
  • Susceptibility to SARS-CoV-2 Infection Among Children and Adolescents Compared With Adults
    A Systematic Review and Meta-analysis
    Russell M. Viner, PhD1; Oliver T. Mytton, PhD2; Chris Bonell, PhD3; et al G. J. Melendez-Torres, PhD4; Joseph Ward, MBBS1; Lee Hudson, PhD1; Claire Waddington, DPhil5; James Thomas, PhD6; Simon Russell, PhD1; Fiona van der Klis, PhD7; Archana Koirala, MBChB8; Shamez Ladhani, MD9; Jasmina Panovska-Griffiths, PhD10; Nicholas G. Davies, DPhil3; Robert Booy, MD8; Rosalind M. Eggo, PhD3
    Author Affiliations Article Information
    JAMA Pediatr. Published online September 25, 2020. doi:10.1001/jamapediatrics.2020.4573

    Abstract
    Importance  The degree to which children and adolescents are infected by and transmit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unclear. The role of children and adolescents in transmission of SARS-CoV-2 is dependent on susceptibility, symptoms, viral load, social contact patterns, and behavior.

    Objective  To systematically review the susceptibility to and transmission of SARS-CoV-2 among children and adolescents compared with adults.

  • 原文来源:https://jamanetwork.com/journals/jamapediatrics/fullarticle/2771181?s=03
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  • 《PNAS,9月22日,Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: A living systematic review and meta-analysis》

    • 来源专题:COVID-19科研动态监测
    • 编译者:zhangmin
    • 发布时间:2020-10-14
    • Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: A living systematic review and meta-analysis Diana Buitrago-Garcia , Dianne Egli-Gany , Michel J. Counotte , Stefanie Hossmann, Hira Imeri, Aziz Mert Ipekci, Georgia Salanti, Nicola Low Published: September 22, 2020https://doi.org/10.1371/journal.pmed.1003346 Abstract Background There is disagreement about the level of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We conducted a living systematic review and meta-analysis to address three questions: (1) Amongst people who become infected with SARS-CoV-2, what proportion does not experience symptoms at all during their infection? (2) Amongst people with SARS-CoV-2 infection who are asymptomatic when diagnosed, what proportion will develop symptoms later? (3) What proportion of SARS-CoV-2 transmission is accounted for by people who are either asymptomatic throughout infection or presymptomatic? Methods and findings We searched PubMed, Embase, bioRxiv, and medRxiv using a database of SARS-CoV-2 literature that is updated daily, on 25 March 2020, 20 April 2020, and 10 June 2020. Studies of people with SARS-CoV-2 diagnosed by reverse transcriptase PCR (RT-PCR) that documented follow-up and symptom status at the beginning and end of follow-up or modelling studies were included. One reviewer extracted data and a second verified the extraction, with disagreement resolved by discussion or a third reviewer. Risk of bias in empirical studies was assessed with an adapted checklist for case series, and the relevance and credibility of modelling studies were assessed using a published checklist. We included a total of 94 studies.
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    • 来源专题:COVID-19科研动态监测
    • 编译者:zhangmin
    • 发布时间:2020-05-06
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