Systematic review and meta-analysis of predictive symptoms and comorbidities for severe COVID-19 infection
Vageesh Jain, Jin-Min Yuan
doi: https://doi.org/10.1101/2020.03.15.20035360
Abstract
Background/introduction COVID−19, a novel coronavirus outbreak starting in China, is now a rapidly developing public health emergency of international concern. The clinical spectrum of COVID−19 disease is varied, and identifying factors associated with severe disease has been described as an urgent research priority. It has been noted that elderly patients with pre-existing comorbidities are more vulnerable to more severe disease. However, the specific symptoms and comorbidities that most strongly predict disease severity are unclear. We performed a systematic review and meta-analysis to identify the symptoms and comorbidities predictive of COVID−19 severity.
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