《LANCET,3月4日,Covert COVID-19 and false-positive dengue serology in Singapore》

  • 来源专题:COVID-19科研动态监测
  • 编译者: zhangmin
  • 发布时间:2020-03-05
  • Covert COVID-19 and false-positive dengue serology in Singapore

    Gabriel Yan, Chun Kiat Lee, Lawrence T M Lam, Benedict Yan, Ying Xian Chua, Anita Y N Lim, et al.

    Show all authors

    Published:March 04, 2020DOI:https://doi.org/10.1016/S1473-3099(20)30158-4

    Dengue and coronavirus disease 2019 (COVID-19) are difficult to distinguish because they have shared clinical and laboratory features.1, 2 We describe two patients in Singapore with false-positive results from rapid serological testing for dengue, who were later confirmed to have severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the causative virus of COVID-19.

  • 原文来源:https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30158-4/fulltext
相关报告
  • 《3月4日_隐蔽的COVID-19和新加坡假阳性登革热血清学》

    • 来源专题:COVID-19科研动态监测
    • 编译者:xuwenwhlib
    • 发布时间:2020-03-06
    • 3月4日_隐蔽的COVID-19和新加坡假阳性登革热血清学 1.时间:2020年3月4日 2.机构或团队:新加坡国立大学医学组织;吴腾芳总医院;新加坡国家环境局环境卫生研究所 3.事件概要: The lancet Infectious Diseases于3月4日出版了新加坡国立大学医学组织等发表的通讯论文“Covert COVID-19 and false-positive dengue serology in Singapore”。 文章指出,登革热和2019冠状病毒病疾病(COVID-19)难以区分,因为它们具有共同的临床和实验室特征。该项研究描述了新加坡的两名患者,他们期初进行登革热快速血清学检测呈假阳性结果,后确诊被COVID-19的致病性病毒即严重急性呼吸系统综合征冠状病毒2(SARS-CoV-2)感染。 文章描述,这两名患者均没有既往病史、旅行或接触史。第一例为57岁男性患者,由于发烧和咳嗽3天就诊,经登革热快速测试呈阴性后出院,后因持续发烧,血小板减少症恶化及新发淋巴细胞减少症重新就诊。重复的进行登革热快速检测呈阳性,他因咳嗽和呼吸困难加重而被送往登革热医院。胸部X光片后进行了鼻咽拭子SARS-CoV-2的RT-PCR检测,检测结果呈阳性。针对最初的血清阳性样本和额外的尿液和血液样本再次进行登革热检测呈阴性。因此,最初的登革热血清转化结果被认为是假阳性。 第二例为57岁女性患者,由于发烧、肌痛、轻微咳嗽4天及腹泻2天就诊,登革热测试呈阳性,被判定为进行门诊登革热随访。她因持续发烧、血小板减少症恶化和新发淋巴细胞减少症于2天后重新就诊。该患者肝功能检查异常(天冬氨酸氨基转移酶、丙氨酸氨基转移酶、总胆红素升高),胸部X光检查正常,她因登革热而住院。尽管她的血液计数恢复正常,但她仍持续发热,入院后3天出现呼吸困难。通过鼻咽拭子的RT-PCR检测发现她的SARS-CoV-2呈阳性。重复登革热检测为阴性,较早的血液样本通过RT-PCR登革热也呈阴性。因此,最初的登革热检测结果被认为是假阳性。 作者认为,由于登革热快速检测结果阳性而未能考虑COVID-19,不仅对患者而且对公共卫生都具有严重的影响。作者指出,文中的病例强调对于COVID-19患者,识别假阳性登革热血清学结果的重要性。作者强调迫切需要对SARS-CoV-2进行快速、灵敏和可用的诊断测试,该测试必须高度准确以保护公众健康。 4.附件: 原文链接: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30158-4/fulltext
  • 《LANCET,4月3日,Preparing African anticancer centres in the COVID-19 outbreak》

    • 来源专题:COVID-19科研动态监测
    • 编译者:xuwenwhlib
    • 发布时间:2020-04-04
    • Preparing African anticancer centres in the COVID-19 outbreak Amine Souadka,Amine Benkabbou,Brahim Al Ahmadi,Saber Boutayeb,Mohammed,Anass Majbar Published:April 03, 2020DOI:https://doi.org/10.1016/S1470-2045(20)30216-3 We congratulate Wenhua Liang and colleagues for their Comment laying out the strategic policies against cancer during the COVID-19 outbreak.1 The disease is now spreading rapidly to and within Africa. Like other countries, Morocco had the opportunity to analyse early COVID-19 data and acknowledge that individual-scale policies such as isolation would not stop the pandemic. Morocco adopted large-scale drastic measures early, including constraining mobility with a mandatory restrictive housing and curfew, despite the low number of cases (starting from 60 cases) compared with Europe. We expect that COVID-19 will have a major impact on African countries, with the risk of a rapid health-care system shutdown, due to a pre-existing shortage in material (eg, intensive-care unit beds or protective equipment) and human resources.