登录
 机构网站
  1. 首页
  2. 情报产品
  3. 快讯详情

《MedRxiv，3月13日，Prolonged presence of SARS-CoV-2 in feces of pediatric patients during the convalescent phase》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-03-14

  • Prolonged presence of SARS-CoV-2 in feces of pediatric patients during the convalescent phase

    Yuhan Xing, Wei Ni, Qin Wu, Wenjie Li, Guoju Li, Jianning Tong, Xiufeng Song, Quansheng Xing

    doi: https://doi.org/10.1101/2020.03.11.20033159

    Abstract

    Background: Severe acute respiratory coronavirus 2 (SARS-CoV-2) is a newly identified virus which mainly spreads from person-to-person. Fecal shedding of SARS-CoV-2 has been constantly reported in patients with coronavirus disease 2019 (COVID-19). Most published studies focus on adult populations, whereas data concerning pediatric patients is relatively scarce. Methods: From January 17, 2020 to March 6, 2020, three pediatric cases of COVID-19 were reported in Qingdao, Shandong Province, China. Epidemiological, clinical, laboratory, and radiological characteristics and treatment data of these children were collected.

    *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.

  • 原文来源：https://www.medrxiv.org/content/10.1101/2020.03.11.20033159v1
119浏览量
原文链接
相关报告

  • 《MedRxiv，3月27日，Factors associated with prolonged viral shedding and impact of Lopinavir/Ritonavir treatment in patients with SARS-CoV-2 infection》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-03-30
    • Factors associated with prolonged viral shedding and impact of Lopinavir/Ritonavir treatment in patients with SARS-CoV-2 infection Dan Yan, Xiao-yan Liu, Ya-nan Zhu, Li Huang, Bi-tang Dan, Guo-jun Zhang, Yong-hua Gao doi: https://doi.org/10.1101/2020.03.22.20040832 Abstract Background: The duration of viral shedding is central to guide decisions around isolation precautions and antiviral treatment. However, studies about risk factors associated with prolonged SARS-CoV-2 shedding and the potential impact of Lopinavir/Ritonavir (LPV/r) treatment remain scarce. Methods: In this retrospective study, data were collected from all SARS-CoV-2 infected patients who were admitted to isolation wards and had RT-PCR conversion at the NO.3 People's hospital of Hubei province between 31 January and 09 March 2020. We compared clinical features and SARS-CoV-2 RNA shedding between patients with LPV/r treatment and those without. Logistic regression analysis was employed to evaluate risk factors associated with prolonged viral shedding. *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.
    80浏览量
    原文链接

  • 《3月13日_恢复期儿童患者粪便中长期存在SARS-CoV-2》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-03-14
    • 1.时间：2020年3月13日 2.机构或团队：香港中文大学、青岛市妇女儿童医院 3.事件概要： 香港中文大学等于2020年3月13日在medRxiv上发表题为“Prolonged presence of SARS-CoV-2 in feces of pediatric patients during the convalescent phase”的文章。 文章指出，研究人员收集了2020年1月17日至2020年3月6日中国山东省青岛市报告的3例儿童COVID-19病例的流行病学、临床、实验室、放射学特征和治疗资料；采用实时荧光定量逆转录-聚合酶链反应（RT-PCR）检测咽拭子和粪便标本中的SARS-CoV-2 RNA。文章得到结果：3例儿童病例均为症状出现较早的成人的家庭接触者；目前还没有证据表明该病毒是由儿童传染给他人的；这些儿童的疾病严重程度为轻至中度，发病时发热为最主要的症状（2例体温高于38.5摄氏度）；所有患儿入院时淋巴细胞增多(>4.4*109/L)，白细胞计数正常；一名儿童血清中降钙素原和c反应蛋白水平升高；放射学变化不典型；所有儿童对支持性治疗反应良好；在发热消退后的两周内，呼吸道的SARS-CoV-2被清除；发现所有儿童的粪便中都持续存在病毒RNA；1例患儿在咽拭子检测结果呈阴性8天后，粪便中SARS-CoV-2变为阴性，而另1例患儿滞后20天；一名儿童在呼吸道样本中病毒RNA转化为阴性19天后，粪便中的RT-PCR分析仍然呈阳性。作者得出结论：COVID-19患儿在流行病学、临床、实验室和放射学等方面与成人有很大差异；在受感染儿童的粪便中长时间存在SARS-CoV-2，表明该病毒可能通过粪便排泄传播。作者指出，各级应作出巨大努力，防止在幼儿园和学校重新开学后在儿童中传播该病毒。 4.附件： 原文链接 https://www.medrxiv.org/content/10.1101/2020.03.11.20033159v1
    140浏览量
    原文链接