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《Applied Microbiology，2月14日，2019_nCoV: Rapid classification of betacoronaviruses and identification of traditional Chinese medicine as potential origin of zoonotic coronaviruses》

  • 来源专题：COVID-19科研动态监测
  • 编译者： dingxq
  • 发布时间：2020-02-16

  • 2019_nCoV: Rapid classification of betacoronaviruses and identification of traditional Chinese medicine as potential origin of zoonotic coronaviruses

    Trudy M. Wassenaar Ying Zou

    doi:https://doi.org/10.1111/lam.13285

    Abstract

    The current outbreak of a novel SARS‐like coronavirus, 2019_nCoV, illustrated difficulties in identifying a novel coronavirus and its natural host, as the coding sequences of various Betacoronavirus species can be highly diverse. By means of whole‐genome sequence comparisons, we demonstrate that the non‐coding flanks of the viral genome can be used to correctly separate the recognized four betacoronavirus subspecies. The conservation would be sufficient to define target sequences that could, in theory, classify novel virus species into their subspecies. Only 253 upstream non‐coding sequences of Sarbecovirus are sufficient to identify genetic similarities between species of this subgenus. Further, it was investigated which bat species have commercial value in China, and would thus likely be handled for trading purposes. A number of coronavirus genomes have been published that were obtained from such bat species. These bats are used in Traditional Chinese Medicine, and their handling poses a potential risk to cause zoonotic coronavirus epidemics.

  • 原文来源：https://sfamjournals.onlinelibrary.wiley.com/doi/abs/10.1111/lam.13285
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