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《BioRxiv，3月21日，Replication of SARS-CoV-2 in human respiratory epithelium》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-03-23

  • Replication of SARS-CoV-2 in human respiratory epithelium

    Aleksandra Milewska, Anna Kula-Pacurar, Jakub Wadas, Agnieszka Suder, Artur Szczepanski, Agnieszka Dabrowska, Katarzyna Owczarek, Marek Ochman, Tomasz Stacel, Zenon Rajfur, Pawel Piotr Labaj, Wojciech Branicki, Krzysztof Pyrc

    doi: https://doi.org/10.1101/2020.03.20.999029

    Abstract

    SARS-CoV-2 emerged by the end of 2019 to rapidly spread in 2020. At present, it is of utmost importance to understand the virus biology and to rapidly assess the potential of existing drugs and develop new active compounds. While some animal models for such studies are under development, most of the research is carried out in the Vero E6 cells. Here, we propose fully differentiated human airway epithelium cultures as a model for studies on the SARS-CoV-2. Further, we also provide basic characteristics of the system.

    *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.

  • 原文来源：https://www.biorxiv.org/content/10.1101/2020.03.20.999029v1
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