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《TAJP，5月27日，Treatment of COVID-19 Patients with Convalescent Plasma》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-05-28

  • Treatment of COVID-19 Patients with Convalescent Plasma

    Author links open overlay panelEricSalazarabKatherine K.PerezacMadihaAshrafdJianChenaBrianCastilloaPaul A.ChristensenaTarynEubankcDavid W.BernardabTodd N.EagarabS. WesleyLongabeSishirSubediaRandall J.OlsenabeChristopherLevequeaMary R.SchwartzaMonishaDeyaCherylChavez-EastaJohnRogersaAhmedShehabeldina…James M.Musserabe

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    https://doi.org/10.1016/j.ajpath.2020.05.014

    Abstract

    COVID-19 disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread globally, and no proven treatments are available. Convalescent plasma therapy has been used with varying degrees of success to treat severe microbial infections for more than 100 years. Patients (n = 25) with severe and/or life-threatening COVID-19 disease were enrolled at the Houston Methodist hospitals from March 28 – April 14, 2020. Patients were transfused with convalescent plasma obtained from donors with confirmed SARS-CoV-2 infection and had recovered. The primary study outcome was safety, and the secondary outcome was clinical status at day 14 post-transfusion. Clinical improvement was assessed based on a modified World Health Organization 6-point ordinal scale and laboratory parameters. Viral genome sequencing was performed on donor and recipient strains.

  • 原文来源：https://www.sciencedirect.com/science/article/pii/S0002944020302571
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    • 编译者：zhangmin
    • 发布时间：2020-03-28
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    • 发布时间：2020-02-28
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