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《BioRxiv，3月20日，The first-in-class peptide binder to the SARS-CoV-2 spike protein》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-03-22

  • The first-in-class peptide binder to the SARS-CoV-2 spike protein

    Genwei Zhang, Sebastian Pomplun, Alexander Robert Loftis, Andrei Loas, Bradley L. Pentelute

    doi: https://doi.org/10.1101/2020.03.19.999318

    Abstract

    Coronavirus disease 19 (COVID-19) is an emerging global health crisis. With over 200,000 confirmed cases to date, this pandemic continues to expand, spurring research to discover vaccines and therapies. SARS-CoV-2 is the novel coronavirus responsible for this disease. It initiates entry into human cells by binding to angiotensin-converting enzyme 2 (ACE2) via the receptor binding domain (RBD) of its spike protein (S). Disrupting the SARS-CoV-2-RBD binding to ACE2 with designer drugs has the potential to inhibit the virus from entering human cells, presenting a new modality for therapeutic intervention.

    *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.

  • 原文来源：https://www.biorxiv.org/content/10.1101/2020.03.19.999318v1
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