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《BioRxiv，3月12日，The SARS-CoV-2 exerts a distinctive strategy for interacting with the ACE2 human receptor》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-03-13

  • The SARS-CoV-2 exerts a distinctive strategy for interacting with the ACE2 human receptor

    Esther S Brielle, Dina Schneidman, Michal Linial

    doi: https://doi.org/10.1101/2020.03.10.986398

    Abstract

    The COVID-19 disease has plagued over 110 countries and has resulted in over 4,000 deaths within 10 weeks. We compare the interaction between the human ACE2 receptor and the SARS-CoV-2 spike protein with that of other pathogenic coronaviruses using molecular dynamics simulations. SARS-CoV, SARS-CoV-2, and HCoV-NL63 recognize ACE2 as the natural receptor but present a distinct binding interface to ACE2 and a different network of residue-residue contacts. SARS-CoV and SARS-CoV-2 have comparable binding affinities achieved by balancing energetics and dynamics.

    *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.

  • 原文来源：https://www.biorxiv.org/content/10.1101/2020.03.10.986398v1
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