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《Nature，5月6日，Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-05-07

  • Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages

    Miriam Merad & Jerome C. Martin

    Nature Reviews Immunology (2020)

    Abstract

    The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to more than 200,000 deaths worldwide. Several studies have now established that the hyperinflammatory response induced by SARS-CoV-2 is a major cause of disease severity and death in infected patients. Macrophages are a population of innate immune cells that sense and respond to microbial threats by producing inflammatory molecules that eliminate pathogens and promote tissue repair. However, a dysregulated macrophage response can be damaging to the host, as is seen in the macrophage activation syndrome induced by severe infections, including in infections with the related virus SARS-CoV. Here we describe the potentially pathological roles of macrophages during SARS-CoV-2 infection and discuss ongoing and prospective therapeutic strategies to modulate macrophage activation in patients with COVID-19.

  • 原文来源：https://www.nature.com/articles/s41577-020-0331-4
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