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《JMV，2月5日，Immunoinformatics-aided Identification of T Cell and B Cell Epitopes in the Surface Glycoprotein of 2019-nCoV》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-02-06

  • Immunoinformatics-aided Identification of T Cell and B Cell Epitopes in the Surface Glycoprotein of 2019-nCoV

    Vargab Baruah, Sujoy Bose

    PMID: 32022276 DOI: 10.1002/jmv.25698

    Abstract

    The 2019 novel coronavirus (2019-nCoV) outbreak has caused a large number of deaths with thousands of confirmed cases worldwide, especially in East Asia. This study took an immunoinformatics approach to identify significant cytotoxic T lymphocyte (CTL) and B cell epitopes in the 2019-nCoV surface glycoprotein. Also, interactions between identified CTL epitopes and their corresponding MHC class I supertype representatives prevalent in China were studied by molecular dynamics simulations. We identified five CTL epitopes, three sequential B cell epitopes and five discontinuous B cell epitopes in the viral surface glycoprotein. Also, during simulations, the CTL epitopes were observed to be binding MHC class I peptide-binding grooves via multiple contacts, with continuous hydrogen bonds and salt bridge anchors, indicating their potential in generating immune responses. Some of these identified epitopes can be potential candidates for development of 2019-nCoV vaccines. This article is protected by copyright. All rights reserved.

  • 原文来源：https://pubmed.ncbi.nlm.nih.gov/32022276-immunoinformatics-aided-identification-of-t-cell-and-b-cell-epitopes-in-the-surface-glycoprotein-of-2019-ncov/?from_term=2019+coronavirus&from_filter=years.2020-2020&from_sort=date&from_page=2&from_pos=4
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    • 编译者：xuwenwhlib
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