The Pathogenicity of 2019 Novel Coronavirus in hACE2 Transgenic Mice
Linlin Bao, Wei Deng, Baoying Huang, Hong Gao, Lili Ren, Qiang Wei, Pin Yu, Yanfeng Xu, Jiangning Liu, Feifei Qi, Yajin Qu, Wenling Wang, Fengdi Li, Qi Lv, Jing Xue, Shuran Gong, Mingya Liu, Guanpeng Wang, Shunyi Wang, Linna Zhao, Peipei Liu, Li Zhao, Fei Ye, Huijuan Wang, Weimin Zhou, Na Zhu, Wei Zhen, Haisheng Yu, Xiaojuan Zhang, Zhiqi Song, Li Guo, Lan Chen, Conghui Wang, Ying Wang, Xinmin Wang, Yan Xiao, Qiangming Sun, Hongqi Liu, Fanli Zhu, Chunxia Ma, Lingmei Yan, Mengli Yang, Jun Han, Wenbo Xu, Wenjie Tan, Xiaozhong Peng, Qi Jin, Guizhen Wu, Chuan Qin
doi: https://doi.org/10.1101/2020.02.07.939389
Abstract
2019-nCoV caused pneumonia cases in China has become a public health emergency of international concern (PHEIC). The first priority for prevention and treatment of the disease is to find the pathogenicity of 2019-nCoV in vivo. Weight loss and virus replication were detected in infected-hACE2 mice. The typical histopathology was interstitial pneumonia with significant inflammatory cells infiltration around the bronchioles and blood vessels, and viral antigens were observed in bronchial epithelial cells and alveolar epithelial cells. The phenomenon was not found in wild type mice infected with 2019-nCoV and the mock-infected hACE2 mice. The pathogenicity of 2019-nCoV in hACE2 mice was clarified and the Koch's postulates was fulfilled as well, and the model may facilitate the development of therapeutics and vaccines against 2019-nCoV.
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