Background. This study assessed cancer patients' knowledge and attitudes towards clinical trials (CTs). Methods. A survey was administered to 100/141 cancer outpatients. Results. 82% respondents had heard of CTs, but many could only provide limited definitions and perceived them as high risk. About half had previously been approached to participate in a trial, and 67% had agreed to participate. Factors influencing participation in trials, barriers to recruitment, and suggestions for increased recruitment in clinical trials were identified. Conclusions. The findings suggest general support of CTs. Education programs are needed to raise awareness, reduce fears, and dispel myths about CT participation.