This work showcased the chemoinformatic study of isoxazoline ectoparasiticides: Fluralaner (FLU) and Afoxolaner (AFO) interactions with l-glutamate-gated chloride channels (3RHW). In order to evaluate inhibition thermodynamics, computational approaches such as molecular docking were employed. Results evidenced that FLU-3RHW highest scoring pose presented lower Gibbs free energy and henceforth, lower Ki values than AFO-3RHW. The findings herein reported suggest therefore that computational methods might be useful to study the thermodynamic features of ectoparasiticides used in veterinary care, what might shed further light on their chemical and pharmacological properties.
In the article, the phenomenon of the shadow economy is considered through the prism of existing approaches to its positive or negative assessment. As a result, the author substantiates the thesis that the negative effects of the shadow economy prevail. It has been established that in the evolution of the shadow economy, negative effects begin to dominate completely since it is the negative effect that the property has to accumulate and grow exponentially. In turn, the positive effects are not inherent in the criminalized part of the shadow economy, and only in its limited size. Taking into account the existing negative and positive effects of the shadow economy, it was concluded that the presence of the latter does not eliminate the need for the state to take measures to combat the shadow economy (not only with its criminalized part but also with that which is beyond the framework of criminality).
In the western philosophical and political thinking C. Léfor is considered not only as a famous thinker, but as a key political philosopher of the end of the 20th - early 21st century, the author of the well-known and hotly debated thesis about the emptiness of state power in democracy, democracy as the acquisition of democracy, totalitarianism as a mutation of democracy. In Ukraine, in its return, he remains barely unknown: there are neither translations of his texts, nor any serious reception of his theoretical heritage. At the same time, our state has certain problems on the way of democratic progress, due to its totalitarian past, the rudiments of which can be observed up to this day. So Claude Lefort’s ideas, moving from Marxism to democracy and dedicated to defining the conditions of its occurrence and the peculiarities of functioning, which proceed from the absolute denial of any forms of totalitarianism, are very useful for understanding the main benchmarks of democratic growth in Ukraine. The study examines the main aspects of the formation of Claude Lefort’s philosophical and political views, beginning with his interest in Marxism and Trotskyism, followed by the phenomenology of M. Merlot-Ponty and the study of N. Machiavelli, J. Michele, A. de Tocqueville, the debate with J.-P. Sartre and K. Castriadis, the result of which was formulating his own political conception and understanding of democracy as political modality of finding the truth. The main focus is also directed at the analysis of the decisive guidelines of C. Lefort’s political theory - the concepts of power, conflict, political action, wild democracy, the study of ontological conditions for the existence of a society, which, as shown in the article, were shaped, to a large extent, under the influence of M. Merlot-Ponty and N. Machiavelli. The phenomenological, M. Merlot-Ponty-like interpretation of Machiavelli’s works allows C. Léfor to formulate a negative and positive definition of the social, negative in that sense, that social is not conditioned by absolutely productive relations, positive, since the main characteristic of the social is its controversial nature, the conflict that is the source of political power, where people assert themselves as the subject of politics, and the power is an empty space, and a symbolic institution of the social at the same time.
The article analyzes the peculiarities of using the audiovisual method in teaching students a foreign language, examines the linguistic and psychological prerequisites for the creation of the audiovisual method, describes the introduction of innovative technologies in teaching foreign languages into practice, shows the specifics of the use of the audiovisual method in the classroom during the training process. The purpose of the work is to identify the optimal conditions for teaching students special, professionally-oriented vocabulary, as well as to demonstrate the ways of the full disclosure of the students’ research and creative abilities on the basis of the audiovisual method. The article solves the problems of searching 1) the ways of implementing a foreign language lesson by professionally-oriented vocabulary, 2) optimal directions of activating students’ creative activity when using the audiovisual method. The scientific and practical significance of the article is due to the development and introduction of innovative technology of teaching a foreign language in the pedagogical practice. The paper presents tried-and-tested teaching materials on the use of the audiovisual method in teaching foreign languages, as well as an example of the system of exercises, based on a feature film with the use of the audiovisual method. The article focuses on the effectiveness of the audiovisual method as a means of improving language skills and abilities. The results of this study prove that the use of audiovisual materials in combination with audio texts contributes to the process of deeper learning live speech when studying a foreign language.
The article reveals the peculiarities of material and living conditions of the students of the Sumy State Pedagogical Institute in 1930-1940. On the basis of archival documents, the level of scholarship provision for students during the 30-40 of the XX century was analyzed, and a comparative analysis of the monetary equivalent of state scholarships in relation to workers’ wages was conducted. The authors cite archival sources that confirm the existence of various sources of scholarship support, for example from trade union organizations. It was stated, that the number and the size of scholarships of the students of the Sumy State Pedagogical Institute was gradually increasing, depending on the results of their study. Nevertheless, the scholarship support, as it is evidenced by the archival documents, was not sufficient for a young person to provide himself with basic clothing and treatment needs, also taking into account the fact that students, like all Ukrainian citizens, were forced to give out some of the funds for state loans. The article analyzes the reasons why students were deprived of scholarship, or why its size was diminished: academic debts, missing classes, violation of discipline, etc. The authors analyze the students’ situation after the introduction of compulsory tuition fee at higher educational establishments, increasing the requirements for the quality of education as the main factor in obtaining a scholarship. The article also investigates the problem of providing accommodation for students in hostels. The analysis of archival documents proves that this problem was acute in 1930-1940. It was solved gradually, sometimes without taking into account the interests of student youth. The article cites archival documents, some of which have been introduced into scientific circles for the first time.
Cyclobenzaprine (CBP) is a centrally acting muscle relaxant whose myriad of therapeutic applications imply the need of better understanding its pharmacokinetics and thermodynamics. Henceforth, this work was concerned with an in silico investigation of CBP main metabolizers in the human organism, namely CYP1A2 and CYP3A4. For this purpose, computational methods were employed, such as molecular docking and other semi-empirical approaches. Results evidenced that the model herein depicted for CBP-CYP1A2 may not reproducibly represent the physiological interaction between CBP and this enzyme. Moreover, CBP-CYP3A4 docking results evidence thermodynamic feasibility of the molecular docking model and were further corroborated by literature, what may reproducibly represent a possible interaction between CBP and this macromolecule.
The purpose of the article is to study the peculiarities of the use of information technologies in the organization of accounting at the enterprise. The relevance of the study is due to the fact that effective organization of accounting management at the enterprise is impossible without the use of information technology and its effective usage becomes more and more important in the process of enterprise management. It has been found out that: 1) accounting as one of the functions of management (regardless of the ownership and the type of economic relations) serves the management process at the enterprise, creating more than 80% of the information base of management decisions which are taken; 2) accounting (as a component of the accounting system) is an orderly system for collecting, registering and generalizing information (in a monetary instrument) about the property (movable and immovable, material assets, things owned by a legal entity), obligations (contractual and non-contractual) the entity of the enterprise (enterprises, institutions, organizations) and their movement by methods of overall, uninterrupted and documentary accounting of all business operations. The directions, possibilities and possible benefits from automation of the accounting processes are presented. It has been established that information technologies (as processes of data systematization and information processing) provide automation of the accounting method and other management functions in information systems. The main (key) elements of the accounting method are: 1) documentation; 2) inventory; 3) costing; 4) accounting bills; 5) double entry; 6) balance sheet. The results of the research suggest that the reform of the accounting system in Ukraine, based on international standards (using modern automated and computerized systems in accounting and management) is the basis of information provision of users for their adoption of sound management decisions. The prospect of further research in this area is the study of the conformity of accounting standards to international standards.
The article identifies the features that distinguish the universal use-value from the special consumer value, which allowed to solve the problem of classification of some forms of money as “complete” or “inferior”. It has been determined that universal use-value, in contrast to the special consumer value, reflects, first of all, relations between people, but not between a man and nature, exists only in commodity production relations and is not destroyed when consumed. Thus, money as a universal use-value should not be reproduced as ordinary goods, so its exchange value or purchasing power is not determined by labor costs for its production. This is true both for modern money and for gold money in the past, which also had insignificant “internal” value. Thus, it is necessary either to attribute gold money to “inferior”, or to recognize that the division of money into “valid” and “invalid” has no clear grounds for it. Modern money, in its turn, is not new production relations in comparison to gold money, it is not a new entity, but a new form of money. It has been proved that modern fiat money should not be regarded as the central bank debt obligations, because it is not such by its nature. Because of this, the existing credit mechanism for the emission of modern money and the growth of public and private debts, caused by such a mechanism of emission, is not necessary.
There are a considerable number of studies on the service quality dimensions of banking industries, but little researches were carried out on the product quality dimensions, and this led to the minimal understanding of the impact of product quality dimensions from the customers’ standpoints, This research sought to identify the impact Islamic banking products (Murabahah and Mudarabah) dimensions on customer satisfaction. The study surveyed Islamic bank customers (users of the Islamic bank’s products in Nigeria) using questionnaires to seek responses, a convenient sampling technique was conducted to reach out to customers, and the use of PLS-SEM 3 was employed for the analysis of the data. The result model shows an R2 value of 0.414 (for Murabahah), which means 41 % of the variance in customer satisfaction is explained by the exogenous constructs of perceived quality, cost, convenience and compliance of Murabahah, and R2 value of 0.309 (for Mudarabah) which means 31 % of the variance in customer satisfaction is explained by the exogenous constructs of perceived quality, cost, convenience and compliance of Mudarabah. The values of R2 for Murabahah and Mudarabah show that the constructs were moderate in determining the satisfaction level of customers as they produced 0.414 and 0.309 respectively.
The purpose of the article is to study and develop the main approaches to forming the model of informational and communicative influence of the subjects of ensuring national security in modern states on the source of threats (in response to crisis and emergency situations). On the basis of analysis of literary sources it was determined that the characteristics of the informational and communicative model as the influence of the subjects of ensuring national security on the source of threats presupposes defining its specific features, namely: 1) the existence of the common communicative space; 2) the activity of participants of communication process as subjects of mutual information process, sending information, one participant of communication involves the activity of another, who should also be guided by the motives, goals, intentions of his partner and analyze them appropriately; 3) the activity of the subjects of communication involves an informal “movement of information”, and an active exchange of it; 4) in the process of communication there can be mutual understanding (misunderstanding), which is achieved by the presence of feedback, as well as by the importance of information, provided that the information is not simply received, but also comprehended; 5) the nature of the exchange of information is determined by the possibility of the mutual influence of partners through the system of signs; 6) the effectiveness of communication is measured by the im-portance of the mutual influence of partners; 7) communicative influence is possible only if the person , sending information (communicator) and the person receiving it (the recipient) have a common or similar system of codification and decoding; 8) communication participants should identically understand the situation of dialogue (communication, negotiations; 9) communicative barriers may occur during the information exchange. It was established that informational and communicative influence of the subjects of ensuring national security on the source of threats should be understood as the influence of manipulative nature, not only during communication, but even at distance (overalls, special means, gestures, facial expressions, poses, etc.), due to which it is possible to predict the actions of the offender, as well as further changes in his possible behavioral manifestations in order to prevent and stop illegal actions, where it is obligatory to take into account the qualities which can acquire positive or negative manifestations.