National Science Library, Chinese Academy of Sciences
  登录 机构网站 ENGLISH
您当前的位置是:首页->详细浏览

期刊名称: Developmental Cell
Volume:36    Issue:2        Page:152-163
ISSN:1534-5807

Maternal DNA Methylation Regulates Early Trophoblast Development期刊论文

作者: Branco Miguel R King Michelle Perez-Garcia Vicente Bogutz Aaron B Caley Matthew
DOI:10.1016/j.devcel.2015.12.027

服务链接:
页码: 152-163
被引频次: 45
出版者: Elsevier Inc,CELL PRESS,Elsevier B.V,Cell Press
期刊名称: Developmental Cell
ISSN: 1534-5807
卷期: Volume:36    Issue:2
语言: English
摘要: Critical roles for DNA methylation in embryonic development are well established, but less is known about its roles during trophoblast development, the extraembryonic lineage that gives rise to the placenta. We dissected the role of DNA methylation in trophoblast development by performing mRNA and DNA methylation profiling of mutants. We find that oocyte-derived methylation plays a major role in regulating trophoblast development but that imprinting of the key placental regulator is only partially responsible for these effects. We have identified several methylation-regulated genes associated with trophoblast differentiation that are involved in cell adhesion and migration, potentially affecting trophoblast invasion. Specifically, trophoblast-specific DNA methylation is linked to the silencing of , a Polycomb Repressive Complex 1 protein that drives loss of cell adhesion in methylation-deficient trophoblast. Our results reveal that maternal DNA methylation controls multiple differentiation-related and physiological processes in trophoblast via both imprinting-dependent and -independent mechanisms. Branco et al. dissect the role of DNA methylation in mouse trophoblast development through genome-wide profiling of methylation-deficient mutants. DNA methylation marks carried over from the oocyte play a major role in trophoblast development and cell adhesion, which is partly dependent on silencing of the Polycomb gene .
相关主题: DIFFERENTIAL EXPRESSION, CPG ISLAND METHYLATION, IMPLANTATION, METHYLTRANSFERASES, MOUSE, GENES, TRANSCRIPTION, DNMT3B, CELL DIFFERENTIATION, DEVELOPMENTAL BIOLOGY, MICE LACKING, CELL BIOLOGY, Embryonic Development - genetics, Placenta - embryology, Gene Expression Regulation, Developmental - genetics, Mice, Transgenic, Genomic Imprinting - genetics, Placenta - metabolism, Pregnancy, Cell Differentiation - genetics, DNA Methylation, Animals, Epigenesis, Genetic - genetics, Female, Trophoblasts - cytology, Cell Lineage - genetics, Epigenetic inheritance, Embryonic development, RNA, Methylation, DNA, Medical genetics,

相关文献推荐:

问图书管理员更多图书管理员

学科咨询馆员
学科馆员

电话:
邮件:
问图书馆员

图标说明

在线获取原文 原文传递 详细信息 图书在架状态 图书馆际互借 问图书馆员

常见问题

图书馆开放时间 图书馆位置 借阅要求 您在使用中发现的任何错误,都可以向我们 【报告错误】,非常感谢!

作者信息:×