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期刊名称: Developmental Cell
Volume:36    Issue:2        Page:152-163

Maternal DNA Methylation Regulates Early Trophoblast Development期刊论文

作者: Branco Miguel R King Michelle Perez-Garcia Vicente Bogutz Aaron B Caley Matthew

页码: 152-163
被引频次: 45
出版者: Elsevier Inc,CELL PRESS,Elsevier B.V,Cell Press
期刊名称: Developmental Cell
ISSN: 1534-5807
卷期: Volume:36    Issue:2
语言: English
摘要: Critical roles for DNA methylation in embryonic development are well established, but less is known about its roles during trophoblast development, the extraembryonic lineage that gives rise to the placenta. We dissected the role of DNA methylation in trophoblast development by performing mRNA and DNA methylation profiling of mutants. We find that oocyte-derived methylation plays a major role in regulating trophoblast development but that imprinting of the key placental regulator is only partially responsible for these effects. We have identified several methylation-regulated genes associated with trophoblast differentiation that are involved in cell adhesion and migration, potentially affecting trophoblast invasion. Specifically, trophoblast-specific DNA methylation is linked to the silencing of , a Polycomb Repressive Complex 1 protein that drives loss of cell adhesion in methylation-deficient trophoblast. Our results reveal that maternal DNA methylation controls multiple differentiation-related and physiological processes in trophoblast via both imprinting-dependent and -independent mechanisms. Branco et al. dissect the role of DNA methylation in mouse trophoblast development through genome-wide profiling of methylation-deficient mutants. DNA methylation marks carried over from the oocyte play a major role in trophoblast development and cell adhesion, which is partly dependent on silencing of the Polycomb gene .
相关主题: DIFFERENTIAL EXPRESSION, CPG ISLAND METHYLATION, IMPLANTATION, METHYLTRANSFERASES, MOUSE, GENES, TRANSCRIPTION, DNMT3B, CELL DIFFERENTIATION, DEVELOPMENTAL BIOLOGY, MICE LACKING, CELL BIOLOGY, Embryonic Development - genetics, Placenta - embryology, Gene Expression Regulation, Developmental - genetics, Mice, Transgenic, Genomic Imprinting - genetics, Placenta - metabolism, Pregnancy, Cell Differentiation - genetics, DNA Methylation, Animals, Epigenesis, Genetic - genetics, Female, Trophoblasts - cytology, Cell Lineage - genetics, Epigenetic inheritance, Embryonic development, RNA, Methylation, DNA, Medical genetics,






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