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期刊名称: Maternal & Child Nutrition
Volume:7    Issue:2        Page:59-79
ISSN:1740-8695

Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post‐natal life期刊论文

作者: Brenna J. Thomas
DOI:10.1111/j.1740-8709.2011.00301.x

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页码: 59-79
被引频次: 42
出版者: Blackwell Publishing Ltd,WILEY-BLACKWELL,Wiley Subscription Services, Inc
期刊名称: Maternal & Child Nutrition
ISSN: 1740-8695
卷期: Volume:7    Issue:2
语言: English
摘要: Scores of animal studies demonstrate that seed oils replete with linoleic acid and very low in linolenic acid fed as the exclusive source of fat through pregnancy and lactation result in visual, cognitive, and behavioural deficits in the offspring. Commodity peanut, sunflower, and safflower oils fed to mother rats, guinea pigs, rhesus monkeys, and baboons induce predictable changes in tissue polyunsaturated fatty acid composition that are abnormal in free‐living land mammals as well as changes in neurotransmitter levels, catecholamines, and signalling compounds compared with animals with a supply of ω3 polyunsaturated fatty acid. These diets consistently induce functional deficits in electroretinograms, reflex responses, reward or avoidance induced learning, maze learning, behaviour, and motor development compared with ω3 replete groups. Boosting neural tissue docosahexaenoic acid (DHA) by feeding preformed DHA enhances visual and cognitive function. Though no human randomized controlled trials on minimal ω3 requirements in pregnancy and lactation have been conducted, the weight of animal evidence compellingly shows that randomizing pregnant or lactating humans to diets that include high linoleate oils as the sole source of fat would be frankly unethical because they would result in suboptimal child development. Increasing use of commodity ω3‐deficient oils in developing countries, many in the name of heart health, will limit brain development of the next generation and can be easily corrected at minimal expense by substituting high oleic acid versions of these same oils, in many cases blended with small amounts of α‐linolenic acid oils like flax or perilla oil. Inclusion of DHA in these diets is likely to further enhance visual and neural development.
相关主题: linoleic acid, malnutrition, animal studies, linolenic acid, PUFA, evidence‐based nutrition, Evidence-based nutrition, Animal studies, Linolenic acid, Malnutrition, Linoleic acid, RANDOMIZED CONTROLLED-TRIALS, RHESUS-MONKEYS, evidence-based nutrition, ARACHIDONIC-ACID, SPATIAL-LEARNING TASKS, NUTRITION & DIETETICS, BRAIN DOCOSAHEXAENOIC ACID, PHOSPHOLIPID SUPPLEMENTATION, DEFICIENT RATS, FEMALE RATS, PEDIATRICS, RAT-BRAIN, ALPHA-LINOLENIC ACID, Animals, Newborn, Linoleic Acid - administration & dosage, Lactation, Linoleic Acid - metabolism, Humans, Male, Fatty Acids, Unsaturated - metabolism, Pregnancy, Animals, Animal Nutritional Physiological Phenomena, Plant Oils - metabolism, alpha-Linolenic Acid - metabolism, Fish Oils - metabolism, Female, Fish Oils - administration & dosage, Developing Countries, Plant Oils - administration & dosage, alpha-Linolenic Acid - administration & dosage, Docosahexaenoic Acids - metabolism, Fatty Acids, Unsaturated - administration & dosage, Petroleum mining, Catecholamines, Food and nutrition, Pregnant women, Omega-3 fatty acids, Linolenic acids,

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