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期刊名称: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Volume:29    Issue:1    
ISSN:1672-7347

Relation between genotype of HBV and its clinical manifestation by PCR with genotype-specific primers期刊论文

作者: Wen Zhi-Li Tan De-Ming Hou Zhou-Hua

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期刊名称: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
ISSN: 1672-7347
卷期: Volume:29    Issue:1
语言: Chinese
摘要: To determine the relation between genotype of HBV and its clinical manifestation. Sera of 220 patients from Hunan Province of China, infected chronically with asymptomatic, mild, moderate, severe and fulminant hepatitis hepatitis B, were genotyped by PCR with genotype-specific primers. The results were statistically analyzed. Only genotype B (86.4%) and C (13.6%) were found. With the aggravations of patients' condition, genotype C was found more often (P < 0.05). The levels of alanine aminotransferase (ALT), total bilirubin (TBIL) and HBV-DNA of genotype C was higher than those of genotype B, but there was no statistical difference. However, the ALT elevation rates of genotype C (96.7%) were significantly higher than those of genotype B (75.2%) (P < 0.05). There was no statistical difference in HBeAg rate between genotype B and C in general, but in patients with chronic fulminant hepatitis or aged 21 approximately 30, the HBeAg rates of genotype C (35.0% and 50.0%) were significantly higher than those of geno
相关主题: Humans, Middle Aged, Liver Failure, Acute - virology, Child, Preschool, Genotype, Male, Polymerase Chain Reaction - methods, Hepatitis B, Chronic - virology, Adolescent, Hepatitis B virus - genetics, Adult, Female, Aged, Child,

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