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期刊名称: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Volume:29    Issue:1    
ISSN:1672-7347

Animal model of endometriosis treated with xenogeneic endothelial cells as vaccines in Lewis rats期刊论文

作者: Wu Xian-Qing Lin Qiu-Hua Tao Guang-Shi

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期刊名称: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
ISSN: 1672-7347
卷期: Volume:29    Issue:1
语言: Chinese
摘要: To investigate a new therapy for endometriosis, which can inhibit the angiogenesis of ectopic endometrium. Xeogeneic endothelial cells (human umbilical vein endothelial cells, HUVECs) were used as vaccines, and a variety of controlled cells (including rat aortic endothelial cells and human fibroblast cells) were cultured, fixed and resuspended in PBS. Thirty-six Lewis rats with experimentally induced endometriosis were divided into 6 groups. Group A was treated with HUVECs (1 x 10(5)); Group B was treated with HUVECs (5 x 10(5)); Group C was treated with HUVECs (1 x 10(6)); Group D (a control group) was treated with PBS (0.5 ml); Group E (a control group) was treated with human fibroblast cells (5 x 10(5)); and Group F (a control group) was treated with rat aortic endothelial cells (5 x 10(5)). Microvessel desity (MVD), area and the proliferative index were deteced in different groups 4 weeks after the treatment. The effect of immune serum on rat endothelial cell proliferation in vivo was determined with meth
相关主题: Animals, Endometriosis - therapy, Neovascularization, Pathologic - drug therapy, Cells, Cultured, Rats, Inbred Lew, Angiogenesis Inhibitors - therapeutic use, Rats, Female, Vaccines - therapeutic use, Umbilical Veins - cytology, Disease Models, Animal, Endothelium, Vascular - immunology,

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