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期刊名称: Journal of Central South University (Medical Sciences)
Volume:29    Issue:6        Page:627-630
ISSN:1672-7347

High-sensitive C-reactive protein and Type 2 diabetic nephropathy期刊论文

作者: Liao Lan Lei Min-Xiang Chen Hurling Wu Jia Guo Li-Juan

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页码: 627-630
期刊名称: Journal of Central South University (Medical Sciences)
ISSN: 1672-7347
卷期: Volume:29    Issue:6
语言: English,Chinese
摘要: To prospectively investigate the relationship between high-sensitive C-reactive protein (hs-CRP) and Type 2 diabetic nephropathy. We assayed serum hs-CRP concentration in 55 normal controls, 66 Type 2 diabetic patients without diabetic nephropathy (DN) and 68 Type 2 diabetic patients with DN by ELISA. A 5-year prospective study was designed to investigate the changes of urinary albumin excretion (UAE), serum hs-CRP concentration, and kidney funciton in targeted intervention including blood glucose and blood pressure in 58 diabetic patients without DN at the baseline. Baseline hs-CRP concentration was the highest in Type 2 diabetic patients with DN, followed by Type 2 diabetic patients without DN, and the lowest in normal controls. After 5-year intervention, hs-CRP concentration at the endline was significantly lower than that at the baseline in the patients in whom DN didn't occur at the endline (P < 0.05). But in the patients in whom DN occured at the endline, hs-CRP concentration was slightly lower than that at the baseline (P > 0.05). Both baseline and endline, the hs-CRP concentrations in the patients in whom DN occured at the endline were significantly higher than those without DN at the endline. Higher serum hs-CRP concentration in patients with Type 2 diabetes may be a risk factor that gives rise to DN. To some extent hs-CRP can predict the occurrence of DN in Type 2 diabetic patients.
相关主题: Type 2 diabetes, Diabetic nephropathy, High-sensitive C-reactive protein, Subclinical inflammation, Diabetes Mellitus, Type 2 - blood, C-Reactive Protein - metabolism, Prospective Studies, Follow-Up Studies, Humans, Middle Aged, Risk Factors, Adult, Female, Male, Aged, Diabetic Nephropathies - blood,

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