Journal of Central South University (Medical Sciences)
To explore the curative effects of 1-(3-fluorophenyl)-5-methyl-2- (1H)-pyridone (FMP) on renal fibrosis in rats. The effects of FMP on the cell proliferation and Fn secretion were measured by methyl thiazolyl tetrazolium and enzyme-linked immunoabsorbent assay, respectively. FMP obviously inhibited the proliferation and Fn secretion in rat renal fibroblast 48 hours after the treatment. FMP (1 000 microg/ml) obviously inhibited the proliferation of rat renal fibroblast 24 hours after the treatment. 1-(3-Fluorophenyl) -5-methyl-2-(1H)-pyridone can obviously inhibit the proliferation of rat renal fibroblast, which may be effective for renal interstitial fibrosis prevention and treatment.