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期刊名称: Journal of Central South University (Medical Sciences)
Volume:29    Issue:2        Page:139-141
ISSN:1672-7347

Effects of 1-(3-fluorophenyl)-5-methyl-2-(1H)-pyridone on renal fibroblast in rats期刊论文

作者: Tao Li-Jian Zhang Jun Hu Gao-Yun

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页码: 139-141
期刊名称: Journal of Central South University (Medical Sciences)
ISSN: 1672-7347
卷期: Volume:29    Issue:2
语言: English,Chinese
摘要: To explore the curative effects of 1-(3-fluorophenyl)-5-methyl-2- (1H)-pyridone (FMP) on renal fibrosis in rats. The effects of FMP on the cell proliferation and Fn secretion were measured by methyl thiazolyl tetrazolium and enzyme-linked immunoabsorbent assay, respectively. FMP obviously inhibited the proliferation and Fn secretion in rat renal fibroblast 48 hours after the treatment. FMP (1 000 microg/ml) obviously inhibited the proliferation of rat renal fibroblast 24 hours after the treatment. 1-(3-Fluorophenyl) -5-methyl-2-(1H)-pyridone can obviously inhibit the proliferation of rat renal fibroblast, which may be effective for renal interstitial fibrosis prevention and treatment.
相关主题: Renal interstitial fibrosis, 1-(3-fluorophenyl)-5-methyl-2-(1H)-pyridone, Fibroblast, Animals, Kidney - pathology, Fibroblasts - drug effects, Rats, Fibronectins - secretion, Fibroblasts - cytology, Kidney - cytology, Fibrosis - prevention & control, Pyridones - pharmacology,

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